Zoloft and Grape seed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Grape seed (grape). Common drug interactions include injection site bruising among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Grape seed. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Grape seed?

Grape seed has active ingredients of grape. eHealthMe is studying from 893 Grape seed users. Check the latest studies of Grape seed.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

12 people who take Zoloft and Grape seed together, and have interactions are studied.

Zoloft and Grape seed drug interactions.

What are the common drug interactions of Zoloft and Grape Seed, by gender? *:

female:

Injection site bruising
Injection site erythema (redness at injection site)
Fatigue (feeling of tiredness)
Muscle spasms (muscle contraction)
Muscle twitching
Asthenia (weakness)
Blood pressure diastolic decreased
Blood pressure systolic increased
Body temperature decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

Diarrhoea
Fatigue (feeling of tiredness)
Injection site swelling
Lethargy (tiredness)
Negativism (negative thoughts)
Palpitations (feelings or sensations that your heart is pounding or racing)
Proctalgia (pain in the rectum)
Pruritus (severe itching of the skin)
Rash
Abnormal dreams

What are the common drug interactions of Zoloft and Grape Seed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Injection site bruising
Injection site erythema (redness at injection site)
Muscle spasms (muscle contraction)
Muscle twitching
Flushing (the warm, red condition of human skin)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Skin burning sensation

50-59:

n/a

60+:

Fatigue (feeling of tiredness)
Diarrhoea
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Increased upper airway secretion
Injection site swelling
Lethargy (tiredness)
Negativism (negative thoughts)
Palpitations (feelings or sensations that your heart is pounding or racing)
Proctalgia (pain in the rectum)
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

Stress And Anxiety: 1 person, 8.33%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 1 person, 8.33%
Bladder Disorder: 1 person, 8.33%
Carcinoid Tumor: 1 person, 8.33%
Constipation: 1 person, 8.33%
Corneal Oedema (corneal swelling): 1 person, 8.33%
Essential Tremor: 1 person, 8.33%
Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 8.33%
Hepatitis C: 1 person, 8.33%
Parkinson's Disease: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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