Zoloft and Psyllium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Psyllium (blond psyllium). Common drug interactions include dizziness among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Psyllium. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,801 Zoloft users. Check the latest studies of Zoloft.

What is Psyllium?

Psyllium has active ingredients of blond psyllium. It is often used in constipation. eHealthMe is studying from 4,262 Psyllium users. Check the latest studies of Psyllium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

49 people who take Zoloft and Psyllium together, and have interactions are studied.

What are the common drug interactions of Zoloft and Psyllium, by gender? *:

female:

Dizziness
Nausea (feeling of having an urge to vomit)
Somnolence (a state of near-sleep, a strong desire for sleep)
Adverse drug reaction
Chest discomfort
Dry throat
Dysplasia (enlargement of an organ or tissue)
Dyspnoea (difficult or laboured respiration)
Fibromyalgia (a long-term condition which causes pain all over the body)
Heart rate increased

male:

Diarrhoea
Productive cough
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bacteraemia (presence of bacteria in the blood)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Cardiomegaly (increased size of heart than normal)
Cataract (clouding of the lens inside the eye)
Compression fracture (fracture due to pressure caused by injury)

What are the common drug interactions of Zoloft and Psyllium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Colitis ulcerative (inflammation of colon with ulcer)
Dehydration (dryness resulting from the removal of water)
Hyperkalaemia (damage to or disease of the kidney)
Septic shock (shock due to blood infection)
Small intestinal obstruction (blockage in small intestine)
Postoperative ileus

20-29:

Night blindness (inability to see in night as day)
Visual impairment

30-39:

Hypersensitivity
Abdominal pain
Abnormal dreams
Allergy to plants
Attention deficit/hyperactivity disorder
Blood pressure increased
Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
Cough
Dehydration (dryness resulting from the removal of water)
Dizziness

40-49:

Headache (pain in head)
Abdominal pain
Adverse drug reaction
Chest discomfort
Dehydration (dryness resulting from the removal of water)
Dizziness
Dry throat
Dysplasia (enlargement of an organ or tissue)
Dyspnoea (difficult or laboured respiration)
Fibromyalgia (a long-term condition which causes pain all over the body)

50-59:

Actinomycosis (infection that causes sores, or abscesses)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Alopecia (absence of hair from areas of the body)
Anaemia of malignant disease
Ankle fracture
Aortic arteriosclerosis (hardening of the aortic arteries)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

60+:

Diarrhoea
General physical health deterioration (weak health status)
Asthenia (weakness)
Cough
Drug effect decreased
Fall
Insomnia (sleeplessness)
Joint dislocation (a joint position is changed from normal position)
Malignant neoplasm progression (cancer tumour came back)
Pain

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 15 people, 30.61%
Bone Loss: 14 people, 28.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 10.20%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 10.20%
Drowsiness: 4 people, 8.16%
Colitis (inflammation of colon): 4 people, 8.16%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 6.12%
Cardiac Disorder: 3 people, 6.12%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 6.12%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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