Zoloft and Rinvoq drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Rinvoq (upadacitinib). Common drug interactions include fungal skin infection among females and cardiac disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Rinvoq. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Rinvoq?

Rinvoq has active ingredients of upadacitinib. eHealthMe is studying from 47,375 Rinvoq users. Check the latest studies of Rinvoq.

On Jul, 19, 2026

57 people who take Zoloft and Rinvoq together, and have interactions are studied.

What are the common drug interactions of Zoloft and Rinvoq, by gender? *:

female:

Fungal skin infection
Gait disturbance
Haemoglobin decreased
Hypophagia (reduced food intake)
Impaired healing
Inflammation
Joint stiffness
Joint warmth
Knee deformity (functional disability of knee)
Mouth ulceration (mouth ulcers)

male:

Cardiac disorder
Discomfort
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Cough
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypophagia (reduced food intake)
Oxygen saturation decreased
Pyrexia (fever)

What are the common drug interactions of Zoloft and Rinvoq, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Presyncope
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Pain

30-39:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Surgery

40-49:

Acne (skin problems that cause pimples)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Nerve injury
Pain
Abdominal discomfort
Abdominal pain
Cough
Fatigue (feeling of tiredness)

50-59:

Oral pain
Oral surgery
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Ovarian mass (mass in ovary)
Pelvic pain
Abdominal pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Blood creatine phosphokinase increased
Drug intolerance (drug sensitivity)
Dyskinesia (abnormality or impairment of voluntary movement)

60+:

Back pain
Pulmonary thrombosis (scarring in the lungs)
Wound infection
Contusion (a type of hematoma of tissue in which capillaries)
Fall
Joint swelling
Muscle spasms (muscle contraction)
Constipation
Hyperhidrosis (abnormally increased sweating)
Knee arthroplasty

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 42 people, 73.68%
High Blood Cholesterol: 15 people, 26.32%
Stress And Anxiety: 12 people, 21.05%
Pain: 9 people, 15.79%
High Blood Pressure: 9 people, 15.79%
Cardiac Disorder: 6 people, 10.53%
Thyroid Diseases: 6 people, 10.53%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 8.77%
Muscle Spasms (muscle contraction): 5 people, 8.77%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 7.02%

* Approximation only. Some reports may have incomplete information.

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