Zoloft and Stivarga drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Stivarga (regorafenib). Common drug interactions include diarrhoea among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Stivarga. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Stivarga?

Stivarga has active ingredients of regorafenib. eHealthMe is studying from 9,539 Stivarga users. Check the latest studies of Stivarga.

On Jul, 19, 2026

13 people who take Zoloft and Stivarga together, and have interactions are studied.

What are the common drug interactions of Zoloft and Stivarga, by gender? *:

female:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Vomiting
Cancer pain
Laryngitis (inflammation of the larynx)
Abdominal discomfort
Arthralgia (joint pain)
Blood pressure increased
Colon cancer
Disease progression

male:

Nausea (feeling of having an urge to vomit)
Dehydration (dryness resulting from the removal of water)
Rash
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Anaemia (lack of blood)
Haemorrhage (bleeding)
Blindness
Blood pressure increased
Colon cancer
Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts)

What are the common drug interactions of Zoloft and Stivarga, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Nausea (feeling of having an urge to vomit)

50-59:

Hypoaesthesia (reduced sense of touch or sensation)
Cough
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Lethargy (tiredness)
Nausea (feeling of having an urge to vomit)
Pneumonia
Rash

60+:

Nausea (feeling of having an urge to vomit)
Diarrhoea
Abdominal discomfort
Arthralgia (joint pain)
Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts)
Confusional state
Dehydration (dryness resulting from the removal of water)
Disease progression
Erythema (redness of the skin)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Colon Cancer: 8 people, 61.54%
Rectal Cancer (cancer of rectum): 2 people, 15.38%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 1 person, 7.69%
Stress And Anxiety: 1 person, 7.69%
Pain: 1 person, 7.69%
Metastases To Lung (cancer spreads to lung): 1 person, 7.69%
High Blood Cholesterol: 1 person, 7.69%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 1 person, 7.69%
Colon Cancer Metastatic (cancer of colon spreads to other part of body): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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