Zoloft and Votrient drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoloft (sertraline hydrochloride) and Votrient (pazopanib hydrochloride). Common drug interactions include oropharyngeal pain among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Zoloft and Votrient. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Votrient?

Votrient has active ingredients of pazopanib hydrochloride. It is often used in metastatic renal cell carcinoma. eHealthMe is studying from 25,347 Votrient users. Check the latest studies of Votrient.

On Jul, 12, 2026

56 people who take Zoloft and Votrient together, and have interactions are studied.

What are the common drug interactions of Zoloft and Votrient, by gender? *:

female:

Oropharyngeal pain
Abdominal pain lower
Abdominal pain upper
Adverse reaction
Cough
Drug ineffective
Dyspepsia (indigestion)
Dyspnoea exertional (breathlessness or shortness of breath)
Gastrointestinal necrosis (destruction of gastrointestinal organ)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

male:

Diarrhoea
Headache (pain in head)
Cardiac arrest
Cough
Death
Hepatic enzyme increased
Nausea (feeling of having an urge to vomit)
Blindness
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug ineffective

What are the common drug interactions of Zoloft and Votrient, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood pressure increased
Diarrhoea
Maternal exposure during pregnancy (use of substance during pregnancy)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Premature delivery

30-39:

Diarrhoea
Eructation (release of gas from the digestive tract)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Nausea (feeling of having an urge to vomit)
Death

40-49:

Nodal rhythm (40-50 beats per minute)

50-59:

Fatigue (feeling of tiredness)
Acute left ventricular failure (heart attack)
Blood pressure diastolic decreased
Cardiac failure congestive
Cardiac output decreased
Cardiomyopathy (weakening of the heart muscle)
Chest discomfort
Chest pain
Conduction disorder (serious disorder of the heart not responses proper to impulses)
Diastolic dysfunction

60+:

Disease progression
Death
Blindness
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Visual field defect
Adverse reaction
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Blood pressure increased

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 28 people, 50.00%
Pain: 7 people, 12.50%
High Blood Pressure: 5 people, 8.93%
Skin Ulcer: 4 people, 7.14%
Primary Myelofibrosis (primary disorder of the bone marrow): 4 people, 7.14%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 4 people, 7.14%
Nausea (feeling of having an urge to vomit): 4 people, 7.14%
Muscle Spasms (muscle contraction): 4 people, 7.14%
Insomnia (sleeplessness): 4 people, 7.14%
Hypersensitivity: 4 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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