Zonisamide and Aubagio drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonisamide (zonisamide) and Aubagio (teriflunomide). Common drug interactions include headache among females and gait disturbance among males.

The phase IV clinical study analyzes what interactions people have when they take Zonisamide and Aubagio. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Aubagio?

Aubagio has active ingredients of teriflunomide. It is often used in multiple sclerosis. eHealthMe is studying from 50,041 Aubagio users. Check the latest studies of Aubagio.

On Jul, 16, 2026

42 people who take Zonisamide and Aubagio together, and have interactions are studied.

Zonisamide and Aubagio drug interactions.

What are the common drug interactions of Zonisamide and Aubagio, by gender? *:

female:

Headache (pain in head)
Productive cough
Oropharyngeal pain
Throat irritation
Asthenia (weakness)
Fall
Alopecia (absence of hair from areas of the body)
Hypoaesthesia (reduced sense of touch or sensation)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)

male:

Gait disturbance
Spinal fusion surgery
Oedema peripheral (superficial swelling)
Myalgia (muscle pain)
Pain
Spinal disorder (disease of spine a back bone)

What are the common drug interactions of Zonisamide and Aubagio, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Alopecia (absence of hair from areas of the body)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Balance disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Decreased appetite
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)

30-39:

Drug ineffective
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Progressive multiple sclerosis (chronic autoimmune disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord)

40-49:

Headache (pain in head)
Oropharyngeal pain
Throat irritation
Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Asthenia (weakness)
Drug ineffective
Fall
Limb injury
Pain in extremity

50-59:

Alopecia (absence of hair from areas of the body)
Back pain
Pain in extremity
Arthralgia (joint pain)
Cataract (clouding of the lens inside the eye)
Dementia (madness)
Depression
Diarrhoea
Dizziness
Dysstasia (difficulty in standing)

60+:

Pain in extremity
Arthralgia (joint pain)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Aortic valve disease
Aphasia (damage to the parts of the brain that control language)
Asthenia (weakness)
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Burning sensation
Disturbance in attention
Eye movement disorder

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 11.90%
Urinary Tract Disorder: 3 people, 7.14%
Sleep Disorder: 3 people, 7.14%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 7.14%
Oral Herpes (viral infection of mouth): 3 people, 7.14%
Muscle Spasms (muscle contraction): 3 people, 7.14%
Headache (pain in head): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Zonisamide and Aubagio?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously