Zopiclone and Depakene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zopiclone (eszopiclone) and Depakene (valproic acid). Common drug interactions include peritonitis among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Zopiclone and Depakene. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Zopiclone?

Zopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 54,330 Zopiclone users. Check the latest studies of Zopiclone.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

On Jul, 12, 2026

28 people who take Zopiclone and Depakene together, and have interactions are studied.

Zopiclone and Depakene drug interactions.

What are the common drug interactions of Zopiclone and Depakene, by gender? *:

female:

Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Pneumonia
Pyrexia (fever)
Renal failure acute (rapid kidney dysfunction)
Somnolence (a state of near-sleep, a strong desire for sleep)
Staphylococcal infection (an infection with staphylococcus bacteria)
Suicide attempt
Thrombocytopenia (decrease of platelets in blood)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Tongue discolouration (colour change of tongue)

male:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Alanine aminotransferase increased
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hyperlipidaemia (presence of excess lipids in the blood)
Psychiatric symptom
Abnormal sensation in eye
Anxiety
Beta-n-acetyl-d-glucosaminidase increased
Blood lactate dehydrogenase increased
Blood urea decreased

What are the common drug interactions of Zopiclone and Depakene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Altered state of consciousness (altered state of mind)
Asthenia (weakness)
Sedation
Coma (state of unconsciousness lasting more than six hours)
Suicidal ideation
Drug level above therapeutic
Galactorrhoea (secretion of breast milk in men)
Tardive dyskinesia (a disorder that involves involuntary movements)
Weight increased
Heart rate decreased

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood lactate dehydrogenase increased
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Gamma-glutamyltransferase increased
Generalised erythema (redness of the skin all over the body)
Human herpes virus 6 serology positive
Lymphadenopathy (disease or enlargement of lymph nodes)
Lymphocyte count increased
Lymphocyte stimulation test positive

40-49:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hyperlipidaemia (presence of excess lipids in the blood)
Psychiatric symptom
Alanine aminotransferase increased
Aspartate aminotransferase increased
Beta-n-acetyl-d-glucosaminidase increased
Blood urea decreased
Breath odour
C-reactive protein increased

50-59:

Cholecystitis (infection of gallbladder)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Abnormal sensation in eye
Anxiety
Depression suicidal (suicide depressive disorder)
Depressive symptom
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

60+:

Coma (state of unconsciousness lasting more than six hours)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Pneumonia
Purpura (purplish discoloration of the skin)
Pyrexia (fever)
Somnolence (a state of near-sleep, a strong desire for sleep)
Staphylococcal infection (an infection with staphylococcus bacteria)
Thrombocytopenia (decrease of platelets in blood)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)
Urinary incontinence (inability to control the flow of urine and involuntary urination)

What are the existing conditions these people have? *

Depression: 5 people, 17.86%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 14.29%
Bipolar Disorder (mood disorder): 4 people, 14.29%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Zopiclone and Depakene?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously