Zyprexa and Suboxone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyprexa (olanzapine) and Suboxone (buprenorphine hydrochloride; naloxone hydrochloride). Common drug interactions include drug dependence among females and restlessness among males.

The phase IV clinical study analyzes what interactions people have when they take Zyprexa and Suboxone. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Zyprexa?

Zyprexa has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 64,724 Zyprexa users. Check the latest studies of Zyprexa.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

On Jul, 18, 2026

81 people who take Zyprexa and Suboxone together, and have interactions are studied.

What are the common drug interactions of Zyprexa and Suboxone, by gender? *:

female:

Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hyperglycaemia (high blood sugar)
Hyperhidrosis (abnormally increased sweating)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Overdose
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Vomiting

male:

Restlessness (not able to rest)
Drug dependence
Eating disorder
Fibromyalgia (a long-term condition which causes pain all over the body)
Heart rate increased
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Memory impairment
Migraine (headache)
Weight decreased

What are the common drug interactions of Zyprexa and Suboxone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug dependence
Eating disorder
Fibromyalgia (a long-term condition which causes pain all over the body)
Heart rate increased
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Memory impairment
Migraine (headache)
Pain
Restlessness (not able to rest)

30-39:

Completed suicide (act of taking one's own life)
Chest pain
Pulmonary embolism (blockage of the main artery of the lung)
Abasia (inability to walk)
Alcohol use
Basophil count increased
Bone density decreased
Endocarditis (inflammation in heart muscle)
Eosinophil count increased
Haemoglobin decreased

40-49:

Activities of daily living impaired
Blood cholesterol increased
Blood triglycerides increased
Chronic kidney disease
Death
Depressed mood
Derealisation
Discomfort
Drug dependence
Drug ineffective

50-59:

Breast cancer stage i
Abdominal pain
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Headache (pain in head)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Overdose
Pneumonia

60+:

Cardiac disorder
Androgen deficiency
Leukopenia (less number of white blood cells in blood)
Localised infection (infection at the single location)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Multiple fractures
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Osteoporosis (bones weak and more likely to break)
Prostate cancer
Pulse pressure decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 25 people, 30.86%
Stress And Anxiety: 12 people, 14.81%
Depression: 11 people, 13.58%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 9.88%
Drug Dependence: 7 people, 8.64%

* Approximation only. Some reports may have incomplete information.

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