Cladribine side effects - from FDA reports


In this review, we analyze Cladribine side effects by the time on the drug, gender and age of the people who have side effects while taking Cladribine. The review is based on 1,223 people who have side effects while taking the drug from FDA, and is updated regularly.

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Cladribine

Cladribine has active ingredients of cladribine. (latest outcomes from Cladribine 1,226 users)


On Sep, 16, 2018

1,223 people who take Cladribine are studied.


Number of reports submitted per year:

Cladribine side effects.

Most common side effects over time *:

< 1 month:
  • Febrile neutropenia (fever with reduced white blood cells)
  • Cystitis haemorrhagic (blood in the urine and painful voiding)
  • Drug eruption (adverse drug reaction of the skin)
  • Pneumonia
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
  • Grand mal convulsion (a type of generalized seizure that affects the entire brain)
  • Hypoxia (low oxygen in tissues)
  • Nausea (feeling of having an urge to vomit)
  • Thyroiditis (inflammation of thyroid gland)
1 - 6 months:
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Second primary malignancy (after getting cure a cancer, a new cancer development)
  • Weight decreased
  • Osteoporosis (bones weak and more likely to break)
  • Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
  • Gastric cancer (stomach cancer)
  • Malignant nervous system neoplasm (cancer tumour of brain and spinal cord)
  • Peripheral sensorimotor neuropathy (damage to one or more of your peripheral nerves)
  • Pneumocystis jiroveci pneumonia (fungal infection of the lungs)
  • Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
6 - 12 months:
  • Lung neoplasm malignant (cancer tumour of lung)
  • Maternal exposure during pregnancy (use of substance during pregnancy)
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Pregnancy
  • Richter's syndrome (hairy cell cancer changes in fast growing b cell cancer tumour)
  • Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
  • Nervous system disorder (a general class of medical conditions affecting the nervous system)
  • Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
  • Blast cell crisis
  • Leukostasis (excessive number of white blood cells in blood)
1 - 2 years:
  • Oesophageal carcinoma (cancer tumour of oesophagus)
  • Throat cancer
  • Thrombocytopenia (decrease of platelets in blood)
2 - 5 years:
  • Pyrexia (fever)
10+ years:
  • Pyrexia (fever)
not specified:
  • Thrombocytopenia (decrease of platelets in blood)
  • Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  • Pyrexia (fever)
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Anaemia haemolytic autoimmune (condition in which the immune system attacks the red blood cells, resulting in fewer of these oxygen-transporting cells)
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Autoimmune thrombocytopenia (isolated low platelet count (thrombocytopenia) with normal bone marrow and the absence of other causes of thrombocytopenia)
  • Neutropenia (an abnormally low number of neutrophils)
  • Vomiting
  • Pneumonia

Most common side effects by gender *:

female:
  • Thrombocytopenia (decrease of platelets in blood)
  • Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  • Pneumonia
  • Pyrexia (fever)
  • Vomiting
  • Febrile neutropenia (fever with reduced white blood cells)
  • Neutropenia (an abnormally low number of neutrophils)
  • Refractory cytopenia with multilineage dysplasia (type of cancer in which the bone marrow does not make enough healthy blood cells and there are abnormal (blast) cells in the blood and/or bone marrow)
  • White blood cell count decreased
  • Chronic lymphocytic leukaemia transformation (white blood cell cancer changes in fast growing cancer in lymph node)
male:
  • Thrombocytopenia (decrease of platelets in blood)
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  • Pyrexia (fever)
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Febrile neutropenia (fever with reduced white blood cells)
  • Neutropenia (an abnormally low number of neutrophils)
  • White blood cell count decreased
  • Drug ineffective
  • Septic shock (shock due to blood infection)

Most common side effects by age *:

0-1:
  • Langerhans' cell histiocytosis
  • Venoocclusive disease (small veins in the liver are obstructed)
  • Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  • Febrile neutropenia (fever with reduced white blood cells)
  • Primitive neuroectodermal tumour (neural crest tumour)
  • Respiratory distress (difficulty in breathing)
2-9:
  • Drug ineffective
  • Pyrexia (fever)
  • Streptococcal sepsis (whole body inflammation by streptococcal)
  • Febrile neutropenia (fever with reduced white blood cells)
  • Respiratory distress (difficulty in breathing)
  • Splenomegaly (enlargement of spleen)
  • Thrombocytopenia (decrease of platelets in blood)
  • Treatment failure
  • Acute monocytic leukaemia (a type of blood cancer)
  • Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
10-19:
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Thrombocytopenia (decrease of platelets in blood)
  • Pyrexia (fever)
  • Venoocclusive liver disease (small veins in the liver are obstructed)
  • Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
  • Anaemia (lack of blood)
  • Caecitis (inflammation of the cecum)
  • Death
  • Delayed engraftment
  • Staphylococcal bacteraemia (a bacterial infection of blood)
20-29:
  • Thrombocytopenia (decrease of platelets in blood)
  • Systemic candida (whole body fungal infection)
  • Left ventricular failure (left ventricle fails to contract forcefully)
  • Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
  • Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
  • Respiratory disorder (respiratory disease)
  • Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  • B-lymphocyte count increased
  • Diarrhoea
  • Epistaxis (bleed from the nose)
30-39:
  • Thrombocytopenia (decrease of platelets in blood)
  • Febrile neutropenia (fever with reduced white blood cells)
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Pyrexia (fever)
  • Thyroiditis (inflammation of thyroid gland)
  • Grand mal convulsion (a type of generalized seizure that affects the entire brain)
  • Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
  • Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  • Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
  • Ventricular hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do)
40-49:
  • Thrombocytopenia (decrease of platelets in blood)
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Neutropenia (an abnormally low number of neutrophils)
  • Upper respiratory tract infection
  • Pneumonia
  • Febrile neutropenia (fever with reduced white blood cells)
  • Lung neoplasm malignant (cancer tumour of lung)
  • Neuropathy peripheral (surface nerve damage)
  • Pyrexia (fever)
  • Tonsillitis (inflammation of tonsil)
50-59:
  • Pneumonia
  • Oesophageal carcinoma (cancer tumour of oesophagus)
  • Thrombocytopenia (decrease of platelets in blood)
  • Malignant neoplasm progression (cancer tumour came back)
  • Nervous system disorder (a general class of medical conditions affecting the nervous system)
  • Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  • Stomatococcal infection
  • Hypoxia (low oxygen in tissues)
  • Neuroendocrine carcinoma of the skin (a rare type of cancer that forms on or just beneath the skin, usually in parts of the body that have been exposed to the sun)
  • Pyrexia (fever)
60+:
  • Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Thrombocytopenia (decrease of platelets in blood)
  • Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
  • Pyrexia (fever)
  • Squamous cell carcinoma (a cancer of a kind of epithelial cell)
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
  • Non-small cell lung cancer (type of epithelial lung cancer)
  • Pneumonia

* Approximation only. Some reports may have incomplete information.

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On eHealthMe, Cladribine (cladribine) is often used to treat hairy cell leukaemia. Find out below the conditions the drugs are used for and how effective they are.

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