Cladribine side effects - from FDA reports


In this review, we analyze Cladribine side effects by the time on the drug, gender and age of the people who have side effects while taking Cladribine. The review is based on 1,059 people who have side effects while taking the drug from FDA, and is updated regularly.

Cladribine

Cladribine has active ingredients of cladribine. (latest outcomes from Cladribine 1,062 users)


On Jun, 09, 2018

1,059 people who take Cladribine are studied.


Number of reports submitted per year:

Cladribine side effects.

Most common side effects over time *:

< 1 month:
  • Cystitis haemorrhagic (blood in the urine and painful voiding)
  • Drug eruption (adverse drug reaction of the skin)
  • Febrile neutropenia (fever with reduced white blood cells)
  • Pneumonia
  • Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
  • Grand mal convulsion (a type of generalized seizure that affects the entire brain)
  • Hypoxia (low oxygen in tissues)
  • Nausea (feeling of having an urge to vomit)
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Thyroiditis (inflammation of thyroid gland)
1 - 6 months:
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Weight decreased
  • Osteoporosis (bones weak and more likely to break)
  • Second primary malignancy (after getting cure a cancer, a new cancer development)
  • Gastric cancer (stomach cancer)
  • Malignant nervous system neoplasm (cancer tumour of brain and spinal cord)
  • Peripheral sensorimotor neuropathy (damage to one or more of your peripheral nerves)
  • Pneumocystis jiroveci pneumonia (fungal infection of the lungs)
  • Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
  • Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
6 - 12 months:
  • Maternal exposure during pregnancy (use of substance during pregnancy)
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Pregnancy
  • Richter's syndrome (hairy cell cancer changes in fast growing b cell cancer tumour)
  • Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
  • Nervous system disorder (a general class of medical conditions affecting the nervous system)
  • Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
  • Blast cell crisis
  • Leukostasis (excessive number of white blood cells in blood)
  • Lung neoplasm malignant (cancer tumour of lung)
1 - 2 years:
  • Oesophageal carcinoma (cancer tumour of oesophagus)
  • Throat cancer
2 - 5 years:
  • Pyrexia (fever)
10+ years:
  • Pyrexia (fever)
not specified:
  • Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  • Thrombocytopenia (decrease of platelets in blood)
  • Pyrexia (fever)
  • Anaemia haemolytic autoimmune (condition in which the immune system attacks the red blood cells, resulting in fewer of these oxygen-transporting cells)
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Autoimmune thrombocytopenia (isolated low platelet count (thrombocytopenia) with normal bone marrow and the absence of other causes of thrombocytopenia)
  • Neutropenia (an abnormally low number of neutrophils)
  • Pneumonia
  • Rash maculo-papular (red area on the skin that is covered with small confluent bumps)

Most common side effects by gender *:

female:
  • Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  • Pyrexia (fever)
  • Thrombocytopenia (decrease of platelets in blood)
  • Pneumonia
  • Neutropenia (an abnormally low number of neutrophils)
  • Refractory cytopenia with multilineage dysplasia (type of cancer in which the bone marrow does not make enough healthy blood cells and there are abnormal (blast) cells in the blood and/or bone marrow)
  • Chronic lymphocytic leukaemia transformation (white blood cell cancer changes in fast growing cancer in lymph node)
  • Drug eruption (adverse drug reaction of the skin)
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
male:
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Thrombocytopenia (decrease of platelets in blood)
  • Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  • Pyrexia (fever)
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Neutropenia (an abnormally low number of neutrophils)
  • Febrile neutropenia (fever with reduced white blood cells)
  • Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
  • Squamous cell carcinoma (a cancer of a kind of epithelial cell)
  • White blood cell count decreased

Most common side effects by age *:

0-1:
  • Langerhans' cell histiocytosis
  • Venoocclusive disease (small veins in the liver are obstructed)
  • Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  • Respiratory distress (difficulty in breathing)
2-9:
  • Pyrexia (fever)
  • Febrile neutropenia (fever with reduced white blood cells)
  • Respiratory distress (difficulty in breathing)
  • Splenomegaly (enlargement of spleen)
  • Treatment failure
  • Acute monocytic leukaemia (a type of blood cancer)
  • Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
  • Chimerism (fertilization of two separate ova by two sperm)
  • Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  • Graft versus host disease in skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin)
10-19:
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Pyrexia (fever)
  • Venoocclusive liver disease (small veins in the liver are obstructed)
  • Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
  • Anaemia (lack of blood)
  • Caecitis (inflammation of the cecum)
  • Death
  • Delayed engraftment
  • Staphylococcal bacteraemia (a bacterial infection of blood)
  • Stem cell transplant
20-29:
  • Systemic candida (whole body fungal infection)
  • Thrombocytopenia (decrease of platelets in blood)
  • Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
  • Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
  • B-lymphocyte count increased
  • Diarrhoea
  • Epistaxis (bleed from the nose)
  • Graft versus host disease in skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin)
  • Malignant neoplasm progression (cancer tumour came back)
  • Neutropenia (an abnormally low number of neutrophils)
30-39:
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Pyrexia (fever)
  • Thyroiditis (inflammation of thyroid gland)
  • Grand mal convulsion (a type of generalized seizure that affects the entire brain)
  • Thrombocytopenia (decrease of platelets in blood)
  • Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
  • Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  • Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
  • Ventricular hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do)
  • Adverse drug reaction
40-49:
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Neutropenia (an abnormally low number of neutrophils)
  • Thrombocytopenia (decrease of platelets in blood)
  • Pneumonia
  • Febrile neutropenia (fever with reduced white blood cells)
  • Lung neoplasm malignant (cancer tumour of lung)
  • Neuropathy peripheral (surface nerve damage)
  • Tonsillitis (inflammation of tonsil)
  • Aspergillosis (an infection caused by a fungus called aspergillus)
  • Hepatotoxicity (chemical-driven liver damage)
50-59:
  • Pneumonia
  • Oesophageal carcinoma (cancer tumour of oesophagus)
  • Thrombocytopenia (decrease of platelets in blood)
  • Malignant neoplasm progression (cancer tumour came back)
  • Nervous system disorder (a general class of medical conditions affecting the nervous system)
  • Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  • Hypoxia (low oxygen in tissues)
  • Neuroendocrine carcinoma of the skin (a rare type of cancer that forms on or just beneath the skin, usually in parts of the body that have been exposed to the sun)
  • Pyrexia (fever)
  • Small cell lung cancer (small cell cancer tumour of lung)
60+:
  • Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  • Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  • Thrombocytopenia (decrease of platelets in blood)
  • Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
  • Pyrexia (fever)
  • Non-small cell lung cancer (type of epithelial lung cancer)
  • Pneumonia
  • Squamous cell carcinoma (a cancer of a kind of epithelial cell)
  • White blood cell count decreased
  • Drug eruption (adverse drug reaction of the skin)

* Approximation only. Some reports may have incomplete information.

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