Accutane and Bipolar i disorder - a phase IV clinical study of FDA data

Summary:

Bipolar i disorder is reported as a side effect among people who take Accutane (isotretinoin), especially for people who are male, 10-19 old, have been taking the drug for 1 - 6 months also take Proventil, and have Asthma.

The phase IV clinical study analyzes which people have Bipolar i disorder when taking Accutane. It is created by eHealthMe based on reports of 33,410 people who have side effects when taking Accutane from the FDA, and is updated regularly.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

What is Bipolar i disorder?

Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode) is found to be associated with 381 drugs and 831 conditions by eHealthMe. Check the latest studies of Bipolar i disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

33,410 people reported to have side effects when taking Accutane.
Among them, 51 people (0.15%) have Bipolar i disorder.

Could Accutane cause Bipolar i disorder?

Among these 51 people:

How long have people been on Accutane when they have Bipolar i disorder? *

What is the gender of people who have Bipolar i disorder when taking Accutane? *

female: 39.22 %
male: 60.78 %

What is the age of people who have Bipolar i disorder when taking Accutane? *

What are other drugs people take besides Accutane? *

What are other side effects people have besides Bipolar i disorder? *

Depression: 21 people, 41.18%
Suicidal Ideation: 20 people, 39.22%
Aggression: 14 people, 27.45%
Agitation (state of anxiety or nervous excitement): 13 people, 25.49%
Inflammatory Bowel Disease: 13 people, 25.49%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 13 people, 25.49%
Abdominal Pain: 12 people, 23.53%
Anger: 11 people, 21.57%
Headache (pain in head): 11 people, 21.57%
Suicide Attempt: 11 people, 21.57%

What are the existing conditions these people have? *

Asthma: 4 people, 7.84%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 5.88%
Pain: 2 people, 3.92%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 1.96%
Migraine (headache): 1 person, 1.96%
Metastases To Bone (cancer spreads to bone): 1 person, 1.96%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 1.96%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 1 person, 1.96%
Cheilitis (infection of lips): 1 person, 1.96%
Breast Cancer: 1 person, 1.96%

* Approximation only. Some reports may have incomplete information.

Do you take Accutane and have Bipolar i disorder?

- Check whether Bipolar i disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Accutane:

Accutane (35,221 reports)

Browse all side effects of Accutane:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bipolar i disorder:

Bipolar i disorder (381 drugs)

Browse all the conditions that are associated with Bipolar i disorder:

Bipolar i disorder (831 conditions)

Related publications that referenced our studies

Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on isotretinoin (the active ingredients of Accutane) and Accutane (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.