Acetaminophen and codeine phosphate and Dependence - a phase IV clinical study of FDA data

Summary:

Dependence is reported as a side effect among people who take Acetaminophen and codeine phosphate (acetaminophen; codeine phosphate), especially for people who are female, 40-49 old, also take Stadol, and have Migraine.

The phase IV clinical study analyzes which people have Dependence when taking Acetaminophen and codeine phosphate. It is created by eHealthMe based on reports of 2,908 people who have side effects when taking Acetaminophen and codeine phosphate from the FDA, and is updated regularly.

What is Acetaminophen and codeine phosphate?

Acetaminophen and codeine phosphate has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 3,220 Acetaminophen and codeine phosphate users. Check the latest studies of Acetaminophen and codeine phosphate.

What is Dependence?

Dependence is found to be associated with 413 drugs and 452 conditions by eHealthMe. Check the latest studies of Dependence.

On Jul, 13, 2026

2,908 people reported to have side effects when taking Acetaminophen and codeine phosphate.
Among them, 15 people (0.52%) have Dependence.

Could Acetaminophen and codeine phosphate cause Dependence?

Among these 15 people:

What is the gender of people who have Dependence when taking Acetaminophen and codeine phosphate? *

female: 93.33 %
male: 6.67 %

What is the age of people who have Dependence when taking Acetaminophen and codeine phosphate? *

What are other drugs people take besides Acetaminophen and codeine phosphate? *

What are other side effects people have besides Dependence? *

Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 2 people, 13.33%
Plantar Fasciitis (painful inflammatory process of the plantar fascia): 1 person, 6.67%
Hypoaesthesia (reduced sense of touch or sensation): 1 person, 6.67%
Heart Rate Irregular: 1 person, 6.67%

What are the existing conditions these people have? *

Migraine (headache): 3 people, 20.00%
Headache (pain in head): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Acetaminophen and codeine phosphate and have Dependence?

- Check whether Dependence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acetaminophen and codeine phosphate:

Acetaminophen and codeine phosphate (3,220 reports)

Dependence treatments and more:

Dependence (56,849 reports)

How severe was Dependence and when was it recovered:

Dependence in Acetaminophen and codeine phosphate

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Dependence and drugs with ingredients of acetaminophen; codeine phosphate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acetaminophen and codeine phosphate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dependence:

Dependence (413 drugs)

Browse all the conditions that are associated with Dependence:

Dependence (452 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Acetaminophen and codeine phosphate) and Acetaminophen and codeine phosphate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.