Acetaminophen and codeine phosphate and Melaena - a phase IV clinical study of FDA data

Summary:

Melaena is reported as a side effect among people who take Acetaminophen and codeine phosphate (acetaminophen; codeine phosphate), especially for people who are female, 60+ old, also take Temazepam, and have Depression.

The phase IV clinical study analyzes which people have Melaena when taking Acetaminophen and codeine phosphate. It is created by eHealthMe based on reports of 2,908 people who have side effects when taking Acetaminophen and codeine phosphate from the FDA, and is updated regularly.

What is Acetaminophen and codeine phosphate?

Acetaminophen and codeine phosphate has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 3,220 Acetaminophen and codeine phosphate users. Check the latest studies of Acetaminophen and codeine phosphate.

What is Melaena?

Melaena (the passage of black, tarry stools) is found to be associated with 1,322 drugs and 1,475 conditions by eHealthMe. Check the latest studies of Melaena.

On Jul, 08, 2026

2,908 people reported to have side effects when taking Acetaminophen and codeine phosphate.
Among them, 23 people (0.79%) have Melaena.

Could Acetaminophen and codeine phosphate cause Melaena?

Among these 23 people:

What is the gender of people who have Melaena when taking Acetaminophen and codeine phosphate? *

female: 57.14 %
male: 42.86 %

What is the age of people who have Melaena when taking Acetaminophen and codeine phosphate? *

What are other drugs people take besides Acetaminophen and codeine phosphate? *

What are other side effects people have besides Melaena? *

Gastric Ulcer (stomach ulcer): 10 people, 43.48%
Dizziness: 8 people, 34.78%
Haematemesis (vomiting of blood): 7 people, 30.43%
Haemoglobin Decreased: 6 people, 26.09%
Nausea And Vomiting: 4 people, 17.39%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 4 people, 17.39%
Dyspnea (difficult or laboured breathing): 4 people, 17.39%
Hypovolaemia (a decreased volume of circulating blood in the body): 4 people, 17.39%
Fatigue (feeling of tiredness): 3 people, 13.04%
Diarrhea: 3 people, 13.04%

What are the existing conditions these people have? *

Depression: 7 people, 30.43%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 21.74%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 17.39%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 8.70%
Indigestion: 2 people, 8.70%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 1 person, 4.35%
Pharyngitis Streptococcal (inflammation of the pharynx caused by infection from. streptococcus): 1 person, 4.35%
Nasopharyngitis (inflammation of the nasopharynx): 1 person, 4.35%
Joint Pain: 1 person, 4.35%
High Blood Pressure: 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Acetaminophen and codeine phosphate and have Melaena?

- Check whether Melaena is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acetaminophen and codeine phosphate:

Acetaminophen and codeine phosphate (3,220 reports)

Melaena treatments and more:

Melaena (29,850 reports)

How severe was Melaena and when was it recovered:

Melaena in Acetaminophen and codeine phosphate

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Melaena and drugs with ingredients of acetaminophen; codeine phosphate (171 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acetaminophen and codeine phosphate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Melaena:

Melaena (1,322 drugs)

Browse all the conditions that are associated with Melaena:

Melaena (1,475 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Acetaminophen and codeine phosphate) and Acetaminophen and codeine phosphate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.