Acetaminophen and codeine phosphate and Oedema - a phase IV clinical study of FDA data

Summary:

Oedema is reported as a side effect among people who take Acetaminophen and codeine phosphate (acetaminophen; codeine phosphate), especially for people who are male, 60+ old, also take Doxazosin Mesylate, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Oedema when taking Acetaminophen and codeine phosphate. It is created by eHealthMe based on reports of 2,908 people who have side effects when taking Acetaminophen and codeine phosphate from the FDA, and is updated regularly.

What is Acetaminophen and codeine phosphate?

Acetaminophen and codeine phosphate has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 3,220 Acetaminophen and codeine phosphate users. Check the latest studies of Acetaminophen and codeine phosphate.

What is Oedema?

Oedema (fluid collection in tissue) is found to be associated with 2,219 drugs and 2,310 conditions by eHealthMe. Check the latest studies of Oedema.

On Jul, 12, 2026

2,908 people reported to have side effects when taking Acetaminophen and codeine phosphate.
Among them, 15 people (0.52%) have Oedema.

Could Acetaminophen and codeine phosphate cause Oedema?

Among these 15 people:

What is the gender of people who have Oedema when taking Acetaminophen and codeine phosphate? *

female: 26.67 %
male: 73.33 %

What is the age of people who have Oedema when taking Acetaminophen and codeine phosphate? *

What are other drugs people take besides Acetaminophen and codeine phosphate? *

Gliclazide: 6 people, 40.00%
Enalapril Maleate: 6 people, 40.00%
Aspirin: 6 people, 40.00%
Avandia: 6 people, 40.00%
Doxazosin Mesylate: 6 people, 40.00%
Simvastatin: 5 people, 33.33%
Omeprazole: 4 people, 26.67%
Metformin Hydrochloride: 3 people, 20.00%
Humira: 2 people, 13.33%
Levothyroxine Sodium: 2 people, 13.33%

What are other side effects people have besides Oedema? *

Malaise (a feeling of general discomfort or uneasiness): 8 people, 53.33%
Renal Impairment (severely reduced kidney function): 7 people, 46.67%
High Blood Pressure: 6 people, 40.00%
Dyslipidaemia (abnormal amount of lipids): 6 people, 40.00%
Microalbuminuria (albumin into the urine): 6 people, 40.00%
Macular Oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken): 6 people, 40.00%
Lower Respiratory Tract Infection: 6 people, 40.00%
Liver Function Test Abnormal: 6 people, 40.00%
Left Ventricular Hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 6 people, 40.00%
Enlarged Heart: 6 people, 40.00%

What are the existing conditions these people have? *

Type 2 Diabetes: 6 people, 40.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 13.33%
Osteoporosis (bones weak and more likely to break): 2 people, 13.33%
Indigestion: 2 people, 13.33%
High Blood Pressure: 2 people, 13.33%
High Blood Cholesterol: 2 people, 13.33%
Extravasation (leakage of a fluid): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Acetaminophen and codeine phosphate and have Oedema?

- Check whether Oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acetaminophen and codeine phosphate:

Acetaminophen and codeine phosphate (3,220 reports)

Oedema treatments and more:

Oedema (78,747 reports)

How severe was Oedema and when was it recovered:

Oedema in Acetaminophen and codeine phosphate

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Oedema and drugs with ingredients of acetaminophen; codeine phosphate (368 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acetaminophen and codeine phosphate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oedema:

Oedema (2,219 drugs)

Browse all the conditions that are associated with Oedema:

Oedema (2,310 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Acetaminophen and codeine phosphate) and Acetaminophen and codeine phosphate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.