Acetaminophen and Heart valve surgery - a phase IV clinical study of FDA data

Summary:

Heart valve surgery is reported as a side effect among people who take Acetaminophen (acetaminophen), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Prednisone, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Heart valve surgery when taking Acetaminophen. It is created by eHealthMe based on reports of 181,086 people who have side effects when taking Acetaminophen from the FDA, and is updated regularly.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

What is Heart valve surgery?

Heart valve surgery is found to be associated with 151 drugs and 437 conditions by eHealthMe. Check the latest studies of Heart valve surgery.



On Jul, 05, 2026

181,086 people reported to have side effects when taking Acetaminophen.
Among them, 16 people (0.01%) have Heart valve surgery.

Could Acetaminophen cause Heart valve surgery?

Among these 16 people:

How long have people been on Acetaminophen when they have Heart valve surgery? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Heart valve surgery when taking Acetaminophen? *

  • female: 69.23 %
  • male: 30.77 %

What is the age of people who have Heart valve surgery when taking Acetaminophen? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 11.11 %
  • 60+: 88.89 %

What are other drugs people take besides Acetaminophen? *

  1. Prednisone: 8 people, 50.00%
  2. Zoloft: 5 people, 31.25%
  3. Restasis: 4 people, 25.00%
  4. Methotrexate: 4 people, 25.00%
  5. Methylprednisolone: 4 people, 25.00%
  6. Vitamin D3: 3 people, 18.75%
  7. Folic Acid: 3 people, 18.75%
  8. Calcium: 3 people, 18.75%
  9. Risedronate Sodium: 3 people, 18.75%
  10. Furosemide: 3 people, 18.75%

What are other side effects people have besides Heart valve surgery? *

  1. High Blood Pressure: 3 people, 18.75%
  2. Chest Pain: 3 people, 18.75%
  3. Fall: 3 people, 18.75%
  4. Haemoglobin Decreased: 3 people, 18.75%
  5. Indigestion: 3 people, 18.75%
  6. Productive Cough: 2 people, 12.50%
  7. Cardiac Valve Disease (heart valve disease): 2 people, 12.50%
  8. Hand Fracture: 2 people, 12.50%
  9. Joint Pain: 2 people, 12.50%
  10. Limb Injury: 2 people, 12.50%

What are the existing conditions these people have? *

  1. Vasculitis (inflammation of a blood vessel or blood vessels): 3 people, 18.75%
  2. Immunodeficiency Common Variable: 3 people, 18.75%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 12.50%
  4. Diabetes: 2 people, 12.50%
  5. Nervousness: 1 person, 6.25%
  6. High Blood Pressure: 1 person, 6.25%
  7. Gastritis (inflammation of stomach): 1 person, 6.25%
  8. Depression: 1 person, 6.25%
  9. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 6.25%
  10. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Acetaminophen and have Heart valve surgery?

- Check whether Heart valve surgery is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acetaminophen:

Heart valve surgery treatments and more:

How severe was Heart valve surgery and when was it recovered:

Expand to all the drugs that have ingredients of acetaminophen:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart valve surgery:

Browse all the conditions that are associated with Heart valve surgery:


How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen (the active ingredients of Acetaminophen) and Acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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