Acetaminophen and Rectal discharge - a phase IV clinical study of FDA data

Summary:

Rectal discharge is reported as a side effect among people who take Acetaminophen (acetaminophen), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Azathioprine, and have Crohn's disease.

The phase IV clinical study analyzes which people have Rectal discharge when taking Acetaminophen. It is created by eHealthMe based on reports of 181,086 people who have side effects when taking Acetaminophen from the FDA, and is updated regularly.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

What is Rectal discharge?

Rectal discharge (discharge from rectum) is found to be associated with 176 drugs and 343 conditions by eHealthMe. Check the latest studies of Rectal discharge.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

181,086 people reported to have side effects when taking Acetaminophen.
Among them, 20 people (0.01%) have Rectal discharge.

Could Acetaminophen cause Rectal discharge?

Among these 20 people:

How long have people been on Acetaminophen when they have Rectal discharge? *

What is the gender of people who have Rectal discharge when taking Acetaminophen? *

female: 69.23 %
male: 30.77 %

What is the age of people who have Rectal discharge when taking Acetaminophen? *

What are other drugs people take besides Acetaminophen? *

Azathioprine: 10 people, 50.00%
Hydrocortisone: 9 people, 45.00%
Methylprednisolone: 8 people, 40.00%
Ciprofloxacin: 8 people, 40.00%
Inflectra: 6 people, 30.00%
Fluticasone Propionate: 6 people, 30.00%
Solu-Cortef: 3 people, 15.00%
Omeprazole: 3 people, 15.00%
Flexeril: 2 people, 10.00%
Humira: 2 people, 10.00%

What are other side effects people have besides Rectal discharge? *

Joint Pain: 11 people, 55.00%
High Blood Pressure: 9 people, 45.00%
Fistula (an abnormal connection or passageway between two): 9 people, 45.00%
Secretion Discharge: 8 people, 40.00%
Lymphocyte Count Abnormal: 8 people, 40.00%
Incisional Hernia (hernia caused by an incompletely-healed surgical wound): 8 people, 40.00%
Heart Rate Decreased: 8 people, 40.00%
Myelosuppression (a decrease in the production of blood cells): 8 people, 40.00%
Pain In Extremity: 8 people, 40.00%
Female Genital Tract Fistula (passage in genital tract of female): 8 people, 40.00%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 10 people, 50.00%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 8 people, 40.00%
Fistula (an abnormal connection or passageway between two): 7 people, 35.00%
Seasonal Allergy (allergic condition due to certain season): 2 people, 10.00%
Migraine (headache): 2 people, 10.00%
Depression: 2 people, 10.00%
Abdominal Pain: 2 people, 10.00%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.00%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Acetaminophen and have Rectal discharge?

- Check whether Rectal discharge is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acetaminophen:

Acetaminophen (183,077 reports)

Browse all side effects of Acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Rectal discharge:

Rectal discharge (176 drugs)

Browse all the conditions that are associated with Rectal discharge:

Rectal discharge (343 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen (the active ingredients of Acetaminophen) and Acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.