Actiq and Formication - a phase IV clinical study of FDA data

Summary:

Formication is reported as a side effect among people who take Actiq (fentanyl citrate), especially for people who are male, 10-19 old, have been taking the drug for < 1 month also take Clonazepam, and have Proctalgia.

The phase IV clinical study analyzes which people have Formication when taking Actiq. It is created by eHealthMe based on reports of 27,560 people who have side effects when taking Actiq from the FDA, and is updated regularly.

What is Actiq?

Actiq has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 27,583 Actiq users. Check the latest studies of Actiq.

What is Formication?

Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin) is found to be associated with 561 drugs and 916 conditions by eHealthMe. Check the latest studies of Formication.

On Jan, 18, 2026

27,560 people reported to have side effects when taking Actiq.
Among them, 7 people (0.03%) have Formication.

Among these 7 people:

How long have people been on Actiq when they have Formication? *

What is the gender of people who have Formication when taking Actiq? *

female: 16.67 %
male: 83.33 %

What is the age of people who have Formication when taking Actiq? *

What are other drugs people take besides Actiq? *

What are other side effects people have besides Formication? *

Insomnia (sleeplessness): 7 people, 100.00%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 7 people, 100.00%
Drug Dependence: 5 people, 71.43%
Dental Caries: 4 people, 57.14%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 57.14%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 57.14%
Abdominal Pain: 3 people, 42.86%
Hyperhidrosis (abnormally increased sweating): 3 people, 42.86%
Nausea (feeling of having an urge to vomit): 3 people, 42.86%
Nausea And Vomiting: 3 people, 42.86%

What are the existing conditions these people have? *

Proctalgia (pain in the rectum): 5 people, 71.43%
Depression: 3 people, 42.86%
Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 1 person, 14.29%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 1 person, 14.29%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 14.29%
Muscle Aches (muscle pain): 1 person, 14.29%
Migraine (headache): 1 person, 14.29%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 14.29%
Abdominal Pain: 1 person, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Actiq and have Formication?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actiq:

Actiq (27,583 reports)

Formication treatments and more:

Formication (8,246 reports)

Browse all side effects of Actiq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Formication:

Formication (561 drugs)

Browse all the conditions that are associated with Formication:

Formication (916 conditions)

Drugs similar to Actiq and Formication :

How the study uses the data?

The study uses data from the FDA. It is based on fentanyl citrate (the active ingredients of Actiq) and Actiq (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.