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Actonel and Bundle branch block - a phase IV clinical study of FDA data

Summary:

Bundle branch block is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Celebrex, and have Abdominal discomfort.

The phase IV clinical study analyzes which people have Bundle branch block when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Bundle branch block?

Bundle branch block (disruption in the normal flow of electrical pulses that drive the heart beat) is found to be associated with 231 drugs and 397 conditions by eHealthMe. Check the latest studies of Bundle branch block.

On Jul, 12, 2026

28,929 people reported to have side effects when taking Actonel.
Among them, 13 people (0.04%) have Bundle branch block.

Could Actonel cause Bundle branch block?

Among these 13 people:

How long have people been on Actonel when they have Bundle branch block? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Bundle branch block when taking Actonel? *

  • female: 46.15 %
  • male: 53.85 %

What is the age of people who have Bundle branch block when taking Actonel? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 10 %
  • 50-59: 0.0 %
  • 60+: 90 %

What are other drugs people take besides Actonel? *

  1. Celebrex: 8 people, 61.54%
  2. Zometa: 7 people, 53.85%
  3. Coreg: 7 people, 53.85%
  4. Mitoxantrone: 7 people, 53.85%
  5. Lansoprazole: 7 people, 53.85%
  6. Neulasta: 7 people, 53.85%
  7. Nexium: 7 people, 53.85%
  8. Nifedipine: 7 people, 53.85%
  9. Furosemide: 7 people, 53.85%
  10. Doxycycline: 7 people, 53.85%

What are other side effects people have besides Bundle branch block? *

  1. Hypotension (abnormally low blood pressure): 10 people, 76.92%
  2. Weight Decreased: 9 people, 69.23%
  3. Dehydration (dryness resulting from the removal of water): 9 people, 69.23%
  4. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 9 people, 69.23%
  5. Pericardial Effusion (fluid around the heart): 9 people, 69.23%
  6. Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 8 people, 61.54%
  7. Fall: 8 people, 61.54%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 61.54%
  9. Pain: 8 people, 61.54%
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 8 people, 61.54%

What are the existing conditions these people have? *

  1. High Blood Pressure: 7 people, 53.85%
  2. Abdominal Discomfort: 7 people, 53.85%
  3. Juvenile Arthritis (arthritis-related condition that develops in children or teenagers): 2 people, 15.38%
  4. Breast Cancer In Situ: 2 people, 15.38%
  5. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.69%
  6. Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 7.69%
  7. Multiple Myeloma (cancer of the plasma cells): 1 person, 7.69%
  8. Metastases To Bone (cancer spreads to bone): 1 person, 7.69%
  9. Herpes Zoster: 1 person, 7.69%
  10. Depression: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Bundle branch block?

- Check whether Bundle branch block is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Bundle branch block treatments and more:

How severe was Bundle branch block and when was it recovered:

Expand to all the drugs that have ingredients of risedronate sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bundle branch block:

Browse all the conditions that are associated with Bundle branch block:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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