Adcirca and Restless leg syndrome - a phase IV clinical study of FDA data

Summary:

Restless leg syndrome is reported as a side effect among people who take Adcirca (tadalafil), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Opsumit, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Restless leg syndrome when taking Adcirca. It is created by eHealthMe based on reports of 54,899 people who have side effects when taking Adcirca from the FDA, and is updated regularly.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

What is Restless leg syndrome?

Restless leg syndrome (a powerful urge to move your legs) is found to be associated with 1,242 drugs and 1,936 conditions by eHealthMe. Check the latest studies of Restless leg syndrome.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 12, 2026

54,899 people reported to have side effects when taking Adcirca.
Among them, 88 people (0.16%) have Restless leg syndrome.

Could Adcirca cause Restless leg syndrome?

Among these 88 people:

How long have people been on Adcirca when they have Restless leg syndrome? *

What is the gender of people who have Restless leg syndrome when taking Adcirca? *

female: 84.52 %
male: 15.48 %

What is the age of people who have Restless leg syndrome when taking Adcirca? *

What are other drugs people take besides Adcirca? *

What are other side effects people have besides Restless leg syndrome? *

Diarrhea: 43 people, 48.86%
Dyspnea (difficult or laboured breathing): 39 people, 44.32%
Pain In Extremity: 39 people, 44.32%
Nausea (feeling of having an urge to vomit): 38 people, 43.18%
Headache (pain in head): 37 people, 42.05%
Fatigue (feeling of tiredness): 31 people, 35.23%
Malaise (a feeling of general discomfort or uneasiness): 30 people, 34.09%
Dizziness: 29 people, 32.95%
Abdominal Distension: 25 people, 28.41%
Insomnia (sleeplessness): 24 people, 27.27%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 51 people, 57.95%
Sinusitis (inflammation of sinus): 4 people, 4.55%
Pain: 4 people, 4.55%
Depression: 4 people, 4.55%
Cor Pulmonale Chronic (long lasting enlargement of the right ventricle of the heart): 1 person, 1.14%

* Approximation only. Some reports may have incomplete information.

Do you take Adcirca and have Restless leg syndrome?

- Check whether Restless leg syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Adcirca:

Adcirca (54,957 reports)

Browse all side effects of Adcirca:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Restless leg syndrome:

Restless leg syndrome (1,242 drugs)

Browse all the conditions that are associated with Restless leg syndrome:

Restless leg syndrome (1,936 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tadalafil (the active ingredients of Adcirca) and Adcirca (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.