Advil congestion relief and Insomnia - a phase IV clinical study of FDA data

Summary:

Insomnia is reported as a side effect among people who take Advil congestion relief (ibuprofen; phenylephrine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Escitalopram, and have Nasopharyngitis.

The phase IV clinical study analyzes which people have Insomnia when taking Advil congestion relief. It is created by eHealthMe based on reports of 725 people who have side effects when taking Advil congestion relief from the FDA, and is updated regularly.

What is Advil congestion relief?

Advil congestion relief has active ingredients of ibuprofen; phenylephrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 756 Advil congestion relief users. Check the latest studies of Advil congestion relief.

What is Insomnia?

Insomnia (sleeplessness) is found to be associated with 3,118 drugs and 5,168 conditions by eHealthMe. Check the latest studies of Insomnia.

On Jul, 08, 2026

725 people reported to have side effects when taking Advil congestion relief.
Among them, 21 people (2.9%) have Insomnia.

Could Advil congestion relief cause Insomnia?

Among these 21 people:

How long have people been on Advil congestion relief when they have Insomnia? *

What is the gender of people who have Insomnia when taking Advil congestion relief? *

female: 75 %
male: 25 %

What is the age of people who have Insomnia when taking Advil congestion relief? *

What are other drugs people take besides Advil congestion relief? *

What are other side effects people have besides Insomnia? *

Drug Ineffective: 5 people, 23.81%
Heart Rate Increased: 4 people, 19.05%
Feeling Hot: 3 people, 14.29%
Pain: 3 people, 14.29%
Muscle Spasms (muscle contraction): 3 people, 14.29%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 14.29%
Nausea (feeling of having an urge to vomit): 3 people, 14.29%
Dyspnea (difficult or laboured breathing): 3 people, 14.29%
Dizziness: 3 people, 14.29%
Feeling Abnormal: 2 people, 9.52%

What are the existing conditions these people have? *

Nasopharyngitis (inflammation of the nasopharynx): 5 people, 23.81%
Headache (pain in head): 3 people, 14.29%
Upper Respiratory Tract Congestion: 2 people, 9.52%
Sinus Congestion (blockage of sinus): 2 people, 9.52%
Depression: 2 people, 9.52%
High Blood Pressure: 2 people, 9.52%
Post-Traumatic Stress Disorder: 2 people, 9.52%
Sinus Disorder (disease of sinus): 2 people, 9.52%
Sinus Pain: 2 people, 9.52%
Chronic Thyroiditis (long lasting inflammation of thyroid gland): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Advil congestion relief and have Insomnia?

- Check whether Insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Advil congestion relief:

Advil congestion relief (756 reports)

Insomnia treatments and more:

Insomnia (438,078 reports)

How severe was Insomnia and when was it recovered:

Insomnia in Advil congestion relief

Expand to all the drugs that have ingredients of ibuprofen; phenylephrine hydrochloride:

Insomnia and drugs with ingredients of ibuprofen; phenylephrine hydrochloride (67 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Advil congestion relief:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Insomnia:

Insomnia (3,118 drugs)

Browse all the conditions that are associated with Insomnia:

Insomnia (5,168 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen; phenylephrine hydrochloride (the active ingredients of Advil congestion relief) and Advil congestion relief (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.