Aleve and Osteoradionecrosis - a phase IV clinical study of FDA data

Summary:

Osteoradionecrosis is reported as a side effect among people who take Aleve (naproxen sodium), especially for people who are female, 40-49 old, also take Zometa, and have Neoplasm malignant.

The phase IV clinical study analyzes which people have Osteoradionecrosis when taking Aleve. It is created by eHealthMe based on reports of 68,206 people who have side effects when taking Aleve from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Osteoradionecrosis?

Osteoradionecrosis (irradiation of bones causes damage to osteocytes and impairs the blood supply) is found to be associated with 329 drugs and 166 conditions by eHealthMe. Check the latest studies of Osteoradionecrosis.

On Jul, 27, 2026

68,206 people reported to have side effects when taking Aleve.
Among them, 28 people (0.04%) have Osteoradionecrosis.

Among these 28 people:

What is the gender of people who have Osteoradionecrosis when taking Aleve? *

female: 67.86 %
male: 32.14 %

What is the age of people who have Osteoradionecrosis when taking Aleve? *

What are other drugs people take besides Aleve? *

What are other side effects people have besides Osteoradionecrosis? *

Rashes (redness): 26 people, 92.86%
Anaemia (lack of blood): 26 people, 92.86%
Emotional Distress: 24 people, 85.71%
Hypoaesthesia Oral (reduced sense of touch or sensation in mouth): 24 people, 85.71%
Osteomyelitis (infection of bone): 23 people, 82.14%
Bone Disorder: 23 people, 82.14%
Stress And Anxiety: 20 people, 71.43%
Neuropathy Peripheral (surface nerve damage): 20 people, 71.43%
Swelling: 20 people, 71.43%
Hypoaesthesia (reduced sense of touch or sensation): 20 people, 71.43%

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 16 people, 57.14%
Depression: 13 people, 46.43%
Pain In Jaw: 12 people, 42.86%
Metastases To Bone (cancer spreads to bone): 10 people, 35.71%
Multiple Myeloma (cancer of the plasma cells): 8 people, 28.57%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 8 people, 28.57%
Stress And Anxiety: 3 people, 10.71%
Lung Cancer - Non-Small Cell (lung cancer): 2 people, 7.14%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 2 people, 7.14%
High Blood Cholesterol: 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve and have Osteoradionecrosis?

- Check whether Osteoradionecrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aleve:

Aleve (70,279 reports)

Browse all side effects of Aleve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoradionecrosis:

Osteoradionecrosis (329 drugs)

Browse all the conditions that are associated with Osteoradionecrosis:

Osteoradionecrosis (166 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium (the active ingredients of Aleve) and Aleve (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.