Amitriptyline hydrochloride and Attention deficit hyperactivity disorder - a phase IV clinical study of FDA data

Summary:

Attention deficit hyperactivity disorder is reported as a side effect among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 1 - 2 years also take Sodium Chloride, and have Narcolepsy.

The phase IV clinical study analyzes which people have Attention deficit hyperactivity disorder when taking Amitriptyline hydrochloride. It is created by eHealthMe based on reports of 16,582 people who have side effects when taking Amitriptyline hydrochloride from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Attention deficit hyperactivity disorder?

Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness) is found to be associated with 610 drugs and 1,393 conditions by eHealthMe. Check the latest studies of Attention deficit hyperactivity disorder.

On Jul, 13, 2026

16,582 people reported to have side effects when taking Amitriptyline hydrochloride.
Among them, 15 people (0.09%) have Attention deficit hyperactivity disorder.

Could Amitriptyline hydrochloride cause Attention deficit hyperactivity disorder?

Among these 15 people:

How long have people been on Amitriptyline hydrochloride when they have Attention deficit hyperactivity disorder? *

What is the gender of people who have Attention deficit hyperactivity disorder when taking Amitriptyline hydrochloride? *

female: 57.14 %
male: 42.86 %

What is the age of people who have Attention deficit hyperactivity disorder when taking Amitriptyline hydrochloride? *

What are other drugs people take besides Amitriptyline hydrochloride? *

What are other side effects people have besides Attention deficit hyperactivity disorder? *

Stress And Anxiety: 7 people, 46.67%
Weakness: 6 people, 40.00%
Muscle Spasms (muscle contraction): 6 people, 40.00%
Fatigue (feeling of tiredness): 6 people, 40.00%
Hypoaesthesia (reduced sense of touch or sensation): 5 people, 33.33%
Kidney Stones: 5 people, 33.33%
Restless Leg Syndrome (a powerful urge to move your legs): 5 people, 33.33%
Dyspnea (difficult or laboured breathing): 5 people, 33.33%
Memory Loss: 5 people, 33.33%
Urination - Excessive At Night: 5 people, 33.33%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 26.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 20.00%
Stress And Anxiety: 2 people, 13.33%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 13.33%
Impaired Gastric Emptying: 2 people, 13.33%
Headache (pain in head): 2 people, 13.33%
Furuncle (infection of the hair follicle): 2 people, 13.33%
Drowsiness: 2 people, 13.33%
Weakness: 1 person, 6.67%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Amitriptyline hydrochloride and have Attention deficit hyperactivity disorder?

- Check whether Attention deficit hyperactivity disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Amitriptyline hydrochloride:

Amitriptyline hydrochloride (20,054 reports)

Attention deficit hyperactivity disorder treatments and more:

Attention deficit hyperactivity disorder (120,336 reports)

How severe was Attention deficit hyperactivity disorder and when was it recovered:

Attention deficit hyperactivity disorder in Amitriptyline hydrochloride

Expand to all the drugs that have ingredients of amitriptyline hydrochloride:

Attention deficit hyperactivity disorder and drugs with ingredients of amitriptyline hydrochloride (72 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Amitriptyline hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Attention deficit hyperactivity disorder:

Attention deficit hyperactivity disorder (610 drugs)

Browse all the conditions that are associated with Attention deficit hyperactivity disorder:

Attention deficit hyperactivity disorder (1,393 conditions)

Related publications that referenced our studies

Coskun M, Adak I, "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2017 Oct .
Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .
Lufi D, Bucherman M, Akita M, Cohen R, Sibani C, "The effect of methylphenidate on speech patterns of children with attention deficit disorder", Journal of Behavioral Health, 2012 Jan .
Coskun M, Adak I, "Excessive and frequent menstrual bleeding with methylphenidate in an adolescent girl with attention-deficit hyperactivity disorder", Journal of clinical psychopharmacology, 2017 Oct .
Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .
Lufi D, Bucherman M, Akita M, Cohen R, Sibani C, "The effect of methylphenidate on speech patterns of children with attention deficit disorder", Journal of Behavioral Health, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on amitriptyline hydrochloride (the active ingredients of Amitriptyline hydrochloride) and Amitriptyline hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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