Aspirin and Chronic fatigue syndrome - a phase IV clinical study of FDA data

Summary:

Chronic fatigue syndrome is reported as a side effect among people who take Aspirin (aspirin), especially for people who are female, 60+ old, also take Ibuprofen, and have Narcolepsy.

The phase IV clinical study analyzes which people have Chronic fatigue syndrome when taking Aspirin. It is created by eHealthMe based on reports of 622,087 people who have side effects when taking Aspirin from the FDA, and is updated regularly.

What is Aspirin?

Aspirin has active ingredients of aspirin. It is often used in blood clots. eHealthMe is studying from 632,088 Aspirin users. Check the latest studies of Aspirin.

What is Chronic fatigue syndrome?

Chronic fatigue syndrome (disorder that causes extreme fatigue) is found to be associated with 287 drugs and 790 conditions by eHealthMe. Check the latest studies of Chronic fatigue syndrome.

On Jul, 09, 2026

622,087 people reported to have side effects when taking Aspirin.
Among them, 51 people (0.01%) have Chronic fatigue syndrome.

Could Aspirin cause Chronic fatigue syndrome?

Among these 51 people:

What is the gender of people who have Chronic fatigue syndrome when taking Aspirin? *

female: 76 %
male: 24 %

What is the age of people who have Chronic fatigue syndrome when taking Aspirin? *

What are other drugs people take besides Aspirin? *

What are other side effects people have besides Chronic fatigue syndrome? *

Depression: 21 people, 41.18%
Weakness: 15 people, 29.41%
Anaemia (lack of blood): 15 people, 29.41%
Sleep Apnea Syndrome: 14 people, 27.45%
Nausea (feeling of having an urge to vomit): 14 people, 27.45%
Pain: 14 people, 27.45%
Fatigue (feeling of tiredness): 14 people, 27.45%
Headache (pain in head): 12 people, 23.53%
Joint Pain: 12 people, 23.53%
Dizziness: 12 people, 23.53%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 15.69%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 11.76%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 9.80%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 9.80%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 9.80%
Pain: 5 people, 9.80%
Immunodeficiency Common Variable: 4 people, 7.84%
Primary Immunodeficiency Syndrome: 4 people, 7.84%
Muscle Spasms (muscle contraction): 3 people, 5.88%
Hereditary Angioedema (recurrent episodes of severe swelling): 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Aspirin and have Chronic fatigue syndrome?

- Check whether Chronic fatigue syndrome is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aspirin:

Aspirin (632,088 reports)

Browse all side effects of Aspirin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Chronic fatigue syndrome:

Chronic fatigue syndrome (287 drugs)

Browse all the conditions that are associated with Chronic fatigue syndrome:

Chronic fatigue syndrome (790 conditions)

Related publications that referenced our studies

Alokaily FA, Alghamdi M, Almalki AS, Alhussaini H, "Aspirin induced leukocytoclastic vasculitis, lower gastrointestinal hemorrhage and acute renal failure (mimicking systemic vasculitis)", Saudi medical journal, 2013 Apr .
Alokaily FA, Alghamdi M, Almalki AS, Alhussaini H, "Aspirin induced leukocytoclastic vasculitis, lower gastrointestinal hemorrhage and acute renal failure (mimicking systemic vasculitis)", Saudi medical journal, 2013 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on aspirin (the active ingredients of Aspirin) and Aspirin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.