Avastin and Systemic sclerosis (scleroderma) - a phase IV clinical study of FDA data

Summary:

Systemic sclerosis (scleroderma) is reported as a side effect among people who take Avastin (bevacizumab), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Xeloda, and have Colorectal cancer metastatic.

The phase IV clinical study analyzes which people have Systemic sclerosis (scleroderma) when taking Avastin. It is created by eHealthMe based on reports of 75,729 people who have side effects when taking Avastin from the FDA, and is updated regularly.

What is Avastin?

Avastin has active ingredients of bevacizumab. It is often used in high blood cholesterol. eHealthMe is studying from 76,365 Avastin users. Check the latest studies of Avastin.

What is Systemic sclerosis (scleroderma)?

Systemic sclerosis (scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin) is found to be associated with 495 drugs and 857 conditions by eHealthMe. Check the latest studies of Systemic sclerosis (scleroderma).

On Jul, 14, 2026

75,729 people reported to have side effects when taking Avastin.
Among them, 21 people (0.03%) have Systemic sclerosis (scleroderma).

Could Avastin cause Systemic sclerosis (scleroderma)?

Among these 21 people:

How long have people been on Avastin when they have Systemic sclerosis (scleroderma)? *

What is the gender of people who have Systemic sclerosis (scleroderma) when taking Avastin? *

female: 100 %
male: 0.0 %

What is the age of people who have Systemic sclerosis (scleroderma) when taking Avastin? *

What are other drugs people take besides Avastin? *

What are other side effects people have besides Systemic sclerosis (scleroderma)? *

Fistula (an abnormal connection or passageway between two): 3 people, 14.29%
Interstitial Lung Disease: 2 people, 9.52%
Infection: 2 people, 9.52%
Drug Toxicity: 2 people, 9.52%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 2 people, 9.52%
Acute Kidney Failure: 2 people, 9.52%
Pulmonary Oedema (fluid accumulation in the lungs): 1 person, 4.76%
Pulmonary Necrosis (death of a small area of lung): 1 person, 4.76%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 1 person, 4.76%
Antinuclear Antibody Increased: 1 person, 4.76%

What are the existing conditions these people have? *

Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 7 people, 33.33%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 3 people, 14.29%
Lung Adenocarcinoma Stage Iii (the cancer has spread to nearby tissue or too far away lymph nodes): 2 people, 9.52%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 4.76%
Ovarian Cancer (cancer of ovary): 1 person, 4.76%
Oedema (fluid collection in tissue): 1 person, 4.76%
Metastases To Central Nervous System (cancer spreads to central nervous system): 1 person, 4.76%
Itching: 1 person, 4.76%
Hyperthyroidism (over activity of the thyroid gland): 1 person, 4.76%
Hepatocellular Carcinoma (liver cancer): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Avastin and have Systemic sclerosis (scleroderma)?

- Check whether Systemic sclerosis (scleroderma) is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Avastin:

Avastin (76,365 reports)

Browse all side effects of Avastin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (495 drugs)

Browse all the conditions that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (857 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bevacizumab (the active ingredients of Avastin) and Avastin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.