Benadryl and Salivary gland pain - a phase IV clinical study of FDA data

Summary:

Salivary gland pain is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 30-39 old, also take Tylenol, and have Crohn's disease.

The phase IV clinical study analyzes which people have Salivary gland pain when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Salivary gland pain?

Salivary gland pain is found to be associated with 56 drugs and 276 conditions by eHealthMe. Check the latest studies of Salivary gland pain.

On Jul, 19, 2026

100,139 people reported to have side effects when taking Benadryl.
Among them, 19 people (0.02%) have Salivary gland pain.

Could Benadryl cause Salivary gland pain?

Among these 19 people:

What is the gender of people who have Salivary gland pain when taking Benadryl? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Salivary gland pain when taking Benadryl? *

What are other drugs people take besides Benadryl? *

What are other side effects people have besides Salivary gland pain? *

Infusion Related Reaction: 10 people, 52.63%
Headache (pain in head): 8 people, 42.11%
Fatigue (feeling of tiredness): 8 people, 42.11%
Weight Decreased: 8 people, 42.11%
Pain: 8 people, 42.11%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 8 people, 42.11%
Muscle Spasms (muscle contraction): 7 people, 36.84%
Oropharyngeal Pain: 7 people, 36.84%
Malaise (a feeling of general discomfort or uneasiness): 7 people, 36.84%
Pain In Jaw: 7 people, 36.84%

What are the existing conditions these people have? *

Headache (pain in head): 6 people, 31.58%
Central Nervous System Inflammation (infection of brain or spinal cord): 6 people, 31.58%
Muscle Tightness: 6 people, 31.58%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 31.58%
Vasculitis (inflammation of a blood vessel or blood vessels): 3 people, 15.79%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 10.53%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 5.26%
Cardiac Disorder: 1 person, 5.26%
Cardiac Fibrillation (uncontrolled muscle contraction of heart): 1 person, 5.26%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Salivary gland pain?

- Check whether Salivary gland pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,954 reports)

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Salivary gland pain:

Salivary gland pain (56 drugs)

Browse all the conditions that are associated with Salivary gland pain:

Salivary gland pain (276 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.