Who have Back pain with Benadryl - from FDA reports


Back pain is found among people who take Benadryl, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Tylenol, and have Pain. This study is created by eHealthMe based on reports of 53,315 people who have side effects when taking Benadryl from FDA, and is updated regularly.

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On Feb, 02, 2019

53,315 people reported to have side effects when taking Benadryl.
Among them, 2,074 people (3.89%) have Back pain


Number of reports submitted per year:

Could Benadryl cause Back pain?

Time on Benadryl when people have Back pain *:

  • < 1 month: 82.65 %
  • 1 - 6 months: 9.18 %
  • 6 - 12 months: 4.08 %
  • 1 - 2 years: 2.04 %
  • 2 - 5 years: 1.02 %
  • 5 - 10 years: 1.02 %
  • 10+ years: 0.0 %

Gender of people who have Back pain when taking Benadryl *:

  • female: 68.66 %
  • male: 31.34 %

Age of people who have Back pain when taking Benadryl *:

  • 0-1: 0.12 %
  • 2-9: 0.31 %
  • 10-19: 1.86 %
  • 20-29: 5.59 %
  • 30-39: 10.01 %
  • 40-49: 22.44 %
  • 50-59: 23.99 %
  • 60+: 35.67 %

Top conditions involved for these people *:

  1. Pain: 243 people, 11.72%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 110 people, 5.30%
  3. Breast Cancer: 94 people, 4.53%
  4. Depression: 93 people, 4.48%
  5. High Blood Pressure: 92 people, 4.44%
  6. Osteoporosis (bones weak and more likely to break): 87 people, 4.19%
  7. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 85 people, 4.10%
  8. Metastases To Bone (cancer spreads to bone): 82 people, 3.95%
  9. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 79 people, 3.81%
  10. Multiple Myeloma (cancer of the plasma cells): 74 people, 3.57%

Top co-used drugs for these people *:

  1. Tylenol: 490 people, 23.63%
  2. Zometa: 416 people, 20.06%
  3. Decadron: 407 people, 19.62%
  4. Zofran: 330 people, 15.91%
  5. Oxycontin: 249 people, 12.01%
  6. Neurontin: 241 people, 11.62%
  7. Aredia: 240 people, 11.57%
  8. Ambien: 232 people, 11.19%
  9. Ativan: 229 people, 11.04%
  10. Xanax: 219 people, 10.56%

Top other side effects for these people *:

  1. Fatigue (feeling of tiredness): 679 people, 32.74%
  2. Pain: 659 people, 31.77%
  3. Joint Pain: 622 people, 29.99%
  4. Nausea (feeling of having an urge to vomit): 593 people, 28.59%
  5. Breathing Difficulty: 592 people, 28.54%
  6. Headache (pain in head): 535 people, 25.80%
  7. Stress And Anxiety: 527 people, 25.41%
  8. Chest Pain: 522 people, 25.17%
  9. Pain In Extremity: 498 people, 24.01%
  10. Weakness: 463 people, 22.32%

* Approximation only. Some reports may have incomplete information.

Do you have Back pain while taking Benadryl?


You are not alone:




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Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 57,530 users)

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Benadryl side effects

Browse by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Browse all side effects of Benadryl
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Compare Benadryl to similar drugs:


What would happen?

Predict new side effects and undetected conditions when you take Benadryl and have Back pain


FDA reports used in this study



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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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