Benadryl and Bone erosion - a phase IV clinical study of FDA data

Summary:

Bone erosion is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 60+ old, also take Zometa, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Bone erosion when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Bone erosion?

Bone erosion is found to be associated with 494 drugs and 295 conditions by eHealthMe. Check the latest studies of Bone erosion.

On Jul, 09, 2026

100,139 people reported to have side effects when taking Benadryl.
Among them, 56 people (0.06%) have Bone erosion.

Among these 56 people:

What is the gender of people who have Bone erosion when taking Benadryl? *

female: 72.09 %
male: 27.91 %

What is the age of people who have Bone erosion when taking Benadryl? *

What are other drugs people take besides Benadryl? *

What are other side effects people have besides Bone erosion? *

Oedema Peripheral (superficial swelling): 39 people, 69.64%
Pain: 38 people, 67.86%
Joint Pain: 34 people, 60.71%
Anaemia (lack of blood): 33 people, 58.93%
Weight Decreased: 33 people, 58.93%
Fatigue (feeling of tiredness): 32 people, 57.14%
Osteonecrosis Of Jaw (death of bone of jaw): 32 people, 57.14%
Confusional State: 31 people, 55.36%
Discomfort: 31 people, 55.36%
Pleural Effusion (water on the lungs): 30 people, 53.57%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 22 people, 39.29%
Breast Cancer: 11 people, 19.64%
Prostate Cancer: 10 people, 17.86%
Thrombosis (formation of a blood clot inside a blood vessel): 9 people, 16.07%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 5 people, 8.93%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 8.93%
Ankylosing Spondylitis (type of arthritis affecting the spine): 5 people, 8.93%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 8.93%
Pain: 4 people, 7.14%
Indigestion: 4 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Bone erosion?

- Check whether Bone erosion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,954 reports)

Bone erosion treatments and more:

Bone erosion (4,590 reports)

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone erosion:

Bone erosion (494 drugs)

Browse all the conditions that are associated with Bone erosion:

Bone erosion (295 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.