Benadryl and Gallbladder non-functioning - a phase IV clinical study of FDA data

Summary:

Gallbladder non-functioning is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 20-29 old, also take Yaz, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Gallbladder non-functioning when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,953 Benadryl users. Check the latest studies of Benadryl.

What is Gallbladder non-functioning?

Gallbladder non-functioning is found to be associated with 119 drugs and 440 conditions by eHealthMe. Check the latest studies of Gallbladder non-functioning.

On Mar, 08, 2026

100,139 people reported to have side effects when taking Benadryl.
Among them, 12 people (0.01%) have Gallbladder non-functioning.

Could Benadryl cause Gallbladder non-functioning?

Among these 12 people:

What is the gender of people who have Gallbladder non-functioning when taking Benadryl? *

female: 100 %
male: 0.0 %

What is the age of people who have Gallbladder non-functioning when taking Benadryl? *

What are other drugs people take besides Benadryl? *

Yaz: 7 people, 58.33%
Yasmin: 6 people, 50.00%
Drospirenone And Ethinyl Estradiol: 5 people, 41.67%
Wellbutrin: 5 people, 41.67%
Omeprazole: 3 people, 25.00%
Riboflavin: 3 people, 25.00%
Bactrim Ds: 3 people, 25.00%
Lexapro: 3 people, 25.00%
Maxalt: 3 people, 25.00%
Atrovent: 3 people, 25.00%

What are other side effects people have besides Gallbladder non-functioning? *

Abdominal Pain: 7 people, 58.33%
Stress And Anxiety: 6 people, 50.00%
Cholecystitis Acute (rapid infection of gallbladder): 4 people, 33.33%
Pain: 4 people, 33.33%
Biliary Dilatation: 3 people, 25.00%
Gallbladder Disease: 3 people, 25.00%
Gallstones (stone formation by bile component): 3 people, 25.00%
Colitis (inflammation of colon): 3 people, 25.00%
Choledocholithiasis (stones in the common bile duct): 3 people, 25.00%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 3 people, 25.00%

What are the existing conditions these people have? *

Multiple Allergies (allergy to multiple agents): 5 people, 41.67%
Stress And Anxiety: 5 people, 41.67%
Pain: 4 people, 33.33%
Flatulence (flatus expelled through the anus): 3 people, 25.00%
Sleep Disorder: 2 people, 16.67%
Red Blood Cell Count Decreased: 2 people, 16.67%
Blood Iron Decreased: 2 people, 16.67%
Polycystic Ovary Disease (cysts in the ovaries that occurs when the follicle stops developing): 2 people, 16.67%
Muscle Spasms (muscle contraction): 2 people, 16.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Gallbladder non-functioning?

- Check whether Gallbladder non-functioning is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,953 reports)

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gallbladder non-functioning:

Gallbladder non-functioning (119 drugs)

Browse all the conditions that are associated with Gallbladder non-functioning:

Gallbladder non-functioning (440 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.