Benadryl and Sarcoidosis - a phase IV clinical study of FDA data

Summary:

Sarcoidosis is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Singulair, and have Depression.

The phase IV clinical study analyzes which people have Sarcoidosis when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Sarcoidosis?

Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands) is found to be associated with 552 drugs and 609 conditions by eHealthMe. Check the latest studies of Sarcoidosis.

On Jul, 06, 2026

100,139 people reported to have side effects when taking Benadryl.
Among them, 83 people (0.08%) have Sarcoidosis.

Among these 83 people:

How long have people been on Benadryl when they have Sarcoidosis? *

What is the gender of people who have Sarcoidosis when taking Benadryl? *

female: 96.25 %
male: 3.75 %

What is the age of people who have Sarcoidosis when taking Benadryl? *

What are other drugs people take besides Benadryl? *

What are other side effects people have besides Sarcoidosis? *

Nausea (feeling of having an urge to vomit): 56 people, 67.47%
Pneumonia: 56 people, 67.47%
Nausea And Vomiting: 54 people, 65.06%
Oedema Peripheral (superficial swelling): 50 people, 60.24%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 48 people, 57.83%
Psychotic Disorder: 47 people, 56.63%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 47 people, 56.63%
Hepatotoxicity (chemical-driven liver damage): 47 people, 56.63%
Hepatic Enzyme Increased: 47 people, 56.63%
Nasal Polyps (masses that develop in the lining of the nose): 47 people, 56.63%

What are the existing conditions these people have? *

Depression: 48 people, 57.83%
Psychotic Disorder: 47 people, 56.63%
Hypomania (a mild form of mania, marked by elation and hyperactivity): 47 people, 56.63%
Hiv Infection: 46 people, 55.42%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 43 people, 51.81%
Pain In Extremity: 27 people, 32.53%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 6 people, 7.23%
Seasonal Allergy (allergic condition due to certain season): 6 people, 7.23%
Nausea (feeling of having an urge to vomit): 6 people, 7.23%
Oropharyngeal Pain: 6 people, 7.23%

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Sarcoidosis?

- Check whether Sarcoidosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,954 reports)

Sarcoidosis treatments and more:

Sarcoidosis (11,686 reports)

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sarcoidosis:

Sarcoidosis (552 drugs)

Browse all the conditions that are associated with Sarcoidosis:

Sarcoidosis (609 conditions)

Related publications that referenced our studies

?UPANI? KRMEK DU, BRAJKOVI? I, BEKI? D, KRNI? A, JURKOVI? P, PAVLOVI? T, "CALCIFIED DEEP VEIN THROMBOSIS IN A PATIENT WITH RECURRENT DEEP VEIN THROMBOSIS AND SARCOIDOSIS", Acta Medica Croatica, 2014 Mar .
Khedr YA, Khedr AH, "Sarcoidosis patient: an unexpected reaction to carbonic anhydrase enzyme inhibitor", BMJ case reports, 2013 Jul .
Kang SM, Baek JY, Hwangbo B, Kim HY, Lee GK, Lee HS, "A case of capecitabine-induced sarcoidosis", Tuberculosis and respiratory diseases, 2012 Mar .
?UPANI? KRMEK DU, BRAJKOVI? I, BEKI? D, KRNI? A, JURKOVI? P, PAVLOVI? T, "CALCIFIED DEEP VEIN THROMBOSIS IN A PATIENT WITH RECURRENT DEEP VEIN THROMBOSIS AND SARCOIDOSIS", Acta Medica Croatica, 2014 Mar .
Khedr YA, Khedr AH, "Sarcoidosis patient: an unexpected reaction to carbonic anhydrase enzyme inhibitor", BMJ case reports, 2013 Jul .
Kang SM, Baek JY, Hwangbo B, Kim HY, Lee GK, Lee HS, "A case of capecitabine-induced sarcoidosis", Tuberculosis and respiratory diseases, 2012 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.