Benadryl and Skin blushing/flushing - a phase IV clinical study of FDA data

Summary:

Skin blushing/flushing is reported as a side effect among people who take Benadryl (diphenhydramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Tylenol, and have Relapsing-remitting multiple sclerosis.

The phase IV clinical study analyzes which people have Skin blushing/flushing when taking Benadryl. It is created by eHealthMe based on reports of 100,139 people who have side effects when taking Benadryl from the FDA, and is updated regularly.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

What is Skin blushing/flushing?

Skin blushing/flushing (a sudden reddening of the face, neck) is found to be associated with 2,016 drugs and 2,931 conditions by eHealthMe. Check the latest studies of Skin blushing/flushing.

On Jul, 30, 2026

100,139 people reported to have side effects when taking Benadryl.
Among them, 3,215 people (3.21%) have Skin blushing/flushing.

Could Benadryl cause Skin blushing/flushing?

Among these 3,215 people:

How long have people been on Benadryl when they have Skin blushing/flushing? *

Click here to view more results

What is the gender of people who have Skin blushing/flushing when taking Benadryl? *

Click here to view

What is the age of people who have Skin blushing/flushing when taking Benadryl? *

Click here to view more results

* Approximation only. Some reports may have incomplete information.

Do you take Benadryl and have Skin blushing/flushing?

- Check whether Skin blushing/flushing is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benadryl:

Benadryl (104,954 reports)

Skin blushing/flushing treatments and more:

Skin blushing/flushing (117,676 reports)

How severe was Skin blushing/flushing and when was it recovered:

Skin blushing/flushing in Benadryl

Expand to all the drugs that have ingredients of diphenhydramine hydrochloride:

Skin blushing/flushing and drugs with ingredients of diphenhydramine hydrochloride (4,905 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Benadryl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin blushing/flushing:

Skin blushing/flushing (2,016 drugs)

Browse all the conditions that are associated with Skin blushing/flushing:

Skin blushing/flushing (2,931 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Benadryl) and Benadryl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.