Botox and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Botox (botulinum toxin type a), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Ampyra, and have Gait disturbance.

The phase IV clinical study analyzes which people have Sciatica when taking Botox. It is created by eHealthMe based on reports of 69,984 people who have side effects when taking Botox from the FDA, and is updated regularly.

What is Botox?

Botox has active ingredients of botulinum toxin type a. It is often used in migraine. eHealthMe is studying from 70,512 Botox users. Check the latest studies of Botox.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,145 drugs and 1,422 conditions by eHealthMe. Check the latest studies of Sciatica.

On Jan, 07, 2026

69,984 people reported to have side effects when taking Botox.
Among them, 33 people (0.05%) have Sciatica.

Among these 33 people:

How long have people been on Botox when they have Sciatica? *

What is the gender of people who have Sciatica when taking Botox? *

female: 100 %
male: 0.0 %

What is the age of people who have Sciatica when taking Botox? *

What are other drugs people take besides Botox? *

What are other side effects people have besides Sciatica? *

Gait Disturbance: 20 people, 60.61%
Fatigue (feeling of tiredness): 17 people, 51.52%
Weakness: 15 people, 45.45%
Headache (pain in head): 15 people, 45.45%
Back Pain: 14 people, 42.42%
Insomnia (sleeplessness): 14 people, 42.42%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 12 people, 36.36%
Pain: 12 people, 36.36%
Nausea (feeling of having an urge to vomit): 10 people, 30.30%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 9 people, 27.27%

What are the existing conditions these people have? *

Gait Disturbance: 11 people, 33.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 27.27%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 9 people, 27.27%
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other): 6 people, 18.18%
Pain: 5 people, 15.15%
Osteopenia (a condition where bone mineral density is lower than normal): 4 people, 12.12%
Stress And Anxiety: 3 people, 9.09%
Muscle Spasms (muscle contraction): 3 people, 9.09%
Basedow's Disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones): 3 people, 9.09%
Depression: 3 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Botox and have Sciatica?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Botox:

Botox (70,512 reports)

Sciatica treatments and more:

Sciatica (28,508 reports)

Browse all side effects of Botox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,145 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,422 conditions)

Drugs similar to Botox and Sciatica :

How the study uses the data?

The study uses data from the FDA. It is based on botulinum toxin type a (the active ingredients of Botox) and Botox (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.