Centrum silver and Appendicitis perforated - a phase IV clinical study of FDA data

Summary:

Appendicitis perforated is reported as a side effect among people who take Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are female, 60+ old, also take Folic Acid, and have Bone disorder.

The phase IV clinical study analyzes which people have Appendicitis perforated when taking Centrum silver. It is created by eHealthMe based on reports of 19,412 people who have side effects when taking Centrum silver from the FDA, and is updated regularly.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

What is Appendicitis perforated?

Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts) is found to be associated with 362 drugs and 558 conditions by eHealthMe. Check the latest studies of Appendicitis perforated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

19,412 people reported to have side effects when taking Centrum silver.
Among them, 20 people (0.1%) have Appendicitis perforated.

Could Centrum silver cause Appendicitis perforated?

Among these 20 people:

What is the gender of people who have Appendicitis perforated when taking Centrum silver? *

female: 90 %
male: 10 %

What is the age of people who have Appendicitis perforated when taking Centrum silver? *

What are other drugs people take besides Centrum silver? *

What are other side effects people have besides Appendicitis perforated? *

Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 14 people, 70.00%
Hordeolum (small collection of pus (abscess) on the eyelid): 14 people, 70.00%
Osteomyelitis (infection of bone): 14 people, 70.00%
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back)): 14 people, 70.00%
Pain: 14 people, 70.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 14 people, 70.00%
Kidney Stones: 14 people, 70.00%
Physical Disability: 14 people, 70.00%
Pleural Effusion (water on the lungs): 14 people, 70.00%
Pneumonia: 14 people, 70.00%

What are the existing conditions these people have? *

High Blood Pressure: 2 people, 10.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 10.00%
Bone Disorder: 2 people, 10.00%
Stress And Anxiety: 1 person, 5.00%
High Blood Cholesterol: 1 person, 5.00%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 1 person, 5.00%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 5.00%
Cervix Carcinoma (cancer of cervix): 1 person, 5.00%
Basal Cell Carcinoma (a skin cancer, it rarely metastasizes or kills): 1 person, 5.00%
Back Pain: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Centrum silver and have Appendicitis perforated?

- Check whether Appendicitis perforated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Centrum silver:

Centrum silver (19,997 reports)

Appendicitis perforated treatments and more:

Appendicitis perforated (3,203 reports)

How severe was Appendicitis perforated and when was it recovered:

Appendicitis perforated in Centrum silver

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Appendicitis perforated and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (82 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Centrum silver:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Appendicitis perforated:

Appendicitis perforated (362 drugs)

Browse all the conditions that are associated with Appendicitis perforated:

Appendicitis perforated (558 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Centrum silver) and Centrum silver (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.