Folate and Aggression - a phase IV clinical study of FDA data

Summary:

Aggression is reported as a side effect among people who take Folate (folic acid), especially for people who are male, 2-9 old, also take Vitamin B12, and have Attention deficit hyperactivity disorder.

The phase IV clinical study analyzes which people have Aggression when taking Folate. It is created by eHealthMe based on reports of 5,953 people who have side effects when taking Folate from the FDA, and is updated regularly.

What is Folate?

Folate has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 6,546 Folate users. Check the latest studies of Folate.

What is Aggression?

Aggression is found to be associated with 1,523 drugs and 1,965 conditions by eHealthMe. Check the latest studies of Aggression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

5,953 people reported to have side effects when taking Folate.
Among them, 16 people (0.27%) have Aggression.

Among these 16 people:

What is the gender of people who have Aggression when taking Folate? *

female: 31.25 %
male: 68.75 %

What is the age of people who have Aggression when taking Folate? *

What are other drugs people take besides Folate? *

What are other side effects people have besides Aggression? *

Anger: 5 people, 31.25%
Weight Increased: 4 people, 25.00%
Headache (pain in head): 3 people, 18.75%
Sedation: 3 people, 18.75%
Stress And Anxiety: 3 people, 18.75%
Dizziness: 3 people, 18.75%
Depressed Mood: 3 people, 18.75%
Agitation (state of anxiety or nervous excitement): 3 people, 18.75%
Drug Ineffective: 3 people, 18.75%
Depression: 2 people, 12.50%

What are the existing conditions these people have? *

Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 5 people, 31.25%
Personality Change: 3 people, 18.75%
Disturbance In Attention: 3 people, 18.75%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 18.75%
Cystic Fibrosis (disease of the secretary glands): 2 people, 12.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 6.25%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 6.25%
Hypersensitivity: 1 person, 6.25%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 6.25%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Folate and have Aggression?

- Check whether Aggression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Folate:

Folate (6,546 reports)

Aggression treatments and more:

Aggression (65,312 reports)

Browse all side effects of Folate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aggression:

Aggression (1,523 drugs)

Browse all the conditions that are associated with Aggression:

Aggression (1,965 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on folic acid (the active ingredients of Folate) and Folate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.