Centrum silver and Hypercalcaemia - a phase IV clinical study of FDA data

Summary:

Hypercalcaemia is reported as a side effect among people who take Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are female, 60+ old, also take Zometa, and have Osteoporosis.

The phase IV clinical study analyzes which people have Hypercalcaemia when taking Centrum silver. It is created by eHealthMe based on reports of 19,412 people who have side effects when taking Centrum silver from the FDA, and is updated regularly.

What is Centrum silver?

Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.

What is Hypercalcaemia?

Hypercalcaemia (elevated calcium (ca+) level in the blood) is found to be associated with 1,054 drugs and 1,018 conditions by eHealthMe. Check the latest studies of Hypercalcaemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

19,412 people reported to have side effects when taking Centrum silver.
Among them, 39 people (0.2%) have Hypercalcaemia.

Could Centrum silver cause Hypercalcaemia?

Among these 39 people:

What is the gender of people who have Hypercalcaemia when taking Centrum silver? *

female: 78.95 %
male: 21.05 %

What is the age of people who have Hypercalcaemia when taking Centrum silver? *

What are other drugs people take besides Centrum silver? *

What are other side effects people have besides Hypercalcaemia? *

High Blood Pressure: 19 people, 48.72%
Constipation: 17 people, 43.59%
Fall: 17 people, 43.59%
Back Pain: 17 people, 43.59%
Weight Decreased: 16 people, 41.03%
Nausea (feeling of having an urge to vomit): 16 people, 41.03%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 15 people, 38.46%
Osteonecrosis Of Jaw (death of bone of jaw): 15 people, 38.46%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 14 people, 35.90%
Nausea And Vomiting: 14 people, 35.90%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 14 people, 35.90%
Multiple Myeloma (cancer of the plasma cells): 11 people, 28.21%
High Blood Pressure: 4 people, 10.26%
High Blood Cholesterol: 3 people, 7.69%
Osteopenia (a condition where bone mineral density is lower than normal): 3 people, 7.69%
Gout (uric acid crystals building up in the body): 2 people, 5.13%
Lung Disorder (lung disease): 2 people, 5.13%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.13%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 5.13%
Metastases To Bone (cancer spreads to bone): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

Do you take Centrum silver and have Hypercalcaemia?

- Check whether Hypercalcaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Centrum silver:

Centrum silver (19,997 reports)

Hypercalcaemia treatments and more:

Hypercalcaemia (18,731 reports)

How severe was Hypercalcaemia and when was it recovered:

Hypercalcaemia in Centrum silver

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Hypercalcaemia and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (418 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Centrum silver:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercalcaemia:

Hypercalcaemia (1,054 drugs)

Browse all the conditions that are associated with Hypercalcaemia:

Hypercalcaemia (1,018 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Centrum silver) and Centrum silver (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.