Chantix and Bipolar i disorder - a phase IV clinical study of FDA data

Summary:

Bipolar i disorder is reported as a side effect among people who take Chantix (varenicline tartrate), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Klonopin, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Bipolar i disorder when taking Chantix. It is created by eHealthMe based on reports of 87,716 people who have side effects when taking Chantix from the FDA, and is updated regularly.

What is Chantix?

Chantix has active ingredients of varenicline tartrate. It is often used in quit smoking. eHealthMe is studying from 89,889 Chantix users. Check the latest studies of Chantix.

What is Bipolar i disorder?

Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode) is found to be associated with 380 drugs and 831 conditions by eHealthMe. Check the latest studies of Bipolar i disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

87,716 people reported to have side effects when taking Chantix.
Among them, 87 people (0.1%) have Bipolar i disorder.

Among these 87 people:

How long have people been on Chantix when they have Bipolar i disorder? *

What is the gender of people who have Bipolar i disorder when taking Chantix? *

female: 74.71 %
male: 25.29 %

What is the age of people who have Bipolar i disorder when taking Chantix? *

What are other drugs people take besides Chantix? *

What are other side effects people have besides Bipolar i disorder? *

Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 17 people, 19.54%
Suicidal Ideation: 16 people, 18.39%
Stress And Anxiety: 16 people, 18.39%
Depression: 13 people, 14.94%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 12.64%
Chest Pain: 10 people, 11.49%
Insomnia (sleeplessness): 10 people, 11.49%
Blood Glucose Decreased: 9 people, 10.34%
Diabetes Mellitus Inadequate Control: 9 people, 10.34%
Urinary Tract Infection: 9 people, 10.34%

What are the existing conditions these people have? *

Depression: 14 people, 16.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 16.09%
Nausea (feeling of having an urge to vomit): 11 people, 12.64%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 11.49%
Urinary Retention (the inability to completely or partially empty the bladder): 10 people, 11.49%
Diabetes: 10 people, 11.49%
Sinus Disorder (disease of sinus): 7 people, 8.05%
Stress And Anxiety: 6 people, 6.90%
Pain: 6 people, 6.90%
High Blood Pressure: 5 people, 5.75%

* Approximation only. Some reports may have incomplete information.

Do you take Chantix and have Bipolar i disorder?

- Check whether Bipolar i disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Chantix:

Chantix (89,889 reports)

Browse all side effects of Chantix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bipolar i disorder:

Bipolar i disorder (380 drugs)

Browse all the conditions that are associated with Bipolar i disorder:

Bipolar i disorder (831 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on varenicline tartrate (the active ingredients of Chantix) and Chantix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.