Ciprofloxacin and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Ciprofloxacin (ciprofloxacin), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Folic Acid, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Ciprofloxacin. It is created by eHealthMe based on reports of 21,064 people who have side effects when taking Ciprofloxacin from the FDA, and is updated regularly.

What is Ciprofloxacin?

Ciprofloxacin has active ingredients of ciprofloxacin. It is often used in urinary tract infection. eHealthMe is studying from 22,256 Ciprofloxacin users. Check the latest studies of Ciprofloxacin.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 946 drugs and 1,232 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

21,064 people reported to have side effects when taking Ciprofloxacin.
Among them, 99 people (0.47%) have Knee joint replacement.

Could Ciprofloxacin cause Knee joint replacement?

Among these 99 people:

How long have people been on Ciprofloxacin when they have Knee joint replacement? *

What is the gender of people who have Knee joint replacement when taking Ciprofloxacin? *

female: 39.29 %
male: 60.71 %

What is the age of people who have Knee joint replacement when taking Ciprofloxacin? *

What are other drugs people take besides Ciprofloxacin? *

Folic Acid: 95 people, 95.96%
Irbesartan: 91 people, 91.92%
Enbrel: 91 people, 91.92%
Omeprazole: 89 people, 89.90%
Cabergoline: 89 people, 89.90%
Ezetimibe: 89 people, 89.90%
Oruvail: 88 people, 88.89%
Phyllocontin: 87 people, 87.88%
Venlafaxine Hydrochloride: 86 people, 86.87%
Carbamazepine: 86 people, 86.87%

What are other side effects people have besides Knee joint replacement? *

Arthropathy: 91 people, 91.92%
Lower Respiratory Tract Infection: 91 people, 91.92%
Rashes (redness): 90 people, 90.91%
Abdominal Discomfort: 89 people, 89.90%
Overdose: 84 people, 84.85%
Lung Neoplasm Malignant (cancer tumour of lung): 53 people, 53.54%
Inflammation: 51 people, 51.52%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 49 people, 49.49%
Weight Loss: 28 people, 28.28%
Diarrhea: 13 people, 13.13%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 92 people, 92.93%
Abdominal Discomfort: 89 people, 89.90%
Depression: 89 people, 89.90%
Empty Sella Syndrome (pituitary gland shrinks or becomes flattened): 89 people, 89.90%
Pituitary Tumor: 85 people, 85.86%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 53 people, 53.54%
Itching: 5 people, 5.05%
Reflux Laryngitis (voice disorder caused by backflow of stomach fluids to the throat and voice box area): 5 people, 5.05%
Lower Respiratory Tract Infection: 4 people, 4.04%
High Blood Pressure: 4 people, 4.04%

* Approximation only. Some reports may have incomplete information.

Do you take Ciprofloxacin and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ciprofloxacin:

Ciprofloxacin (22,256 reports)

Browse all side effects of Ciprofloxacin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (946 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,232 conditions)

Related publications that referenced our studies

Bolognesi M, Bolognesi D, "Medicine Ciprofloxacin-induced paroxysmal atrial fibrillation", , 2014 Mar .
Bolognesi M, Bolognesi D, "Ciprofloxacin-induced paroxysmal atrial fibrilation", OA Case Reports, 2012 Jan .
Bolognesi M, Bolognesi D, "Medicine Ciprofloxacin-induced paroxysmal atrial fibrillation", , 2014 Mar .
Bolognesi M, Bolognesi D, "Ciprofloxacin-induced paroxysmal atrial fibrilation", OA Case Reports, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on ciprofloxacin (the active ingredients of Ciprofloxacin) and Ciprofloxacin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.