Clozaril and Osteoarthritis - a phase IV clinical study of FDA data

Summary:

Osteoarthritis is reported as a side effect among people who take Clozaril (clozapine), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Fosamax, and have Depression.

The phase IV clinical study analyzes which people have Osteoarthritis when taking Clozaril. It is created by eHealthMe based on reports of 64,938 people who have side effects when taking Clozaril from the FDA, and is updated regularly.

What is Clozaril?

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 65,127 Clozaril users. Check the latest studies of Clozaril.

What is Osteoarthritis?

Osteoarthritis (a joint disease caused by cartilage loss in a joint) is found to be associated with 1,878 drugs and 2,647 conditions by eHealthMe. Check the latest studies of Osteoarthritis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 31, 2026

64,938 people reported to have side effects when taking Clozaril.
Among them, 39 people (0.06%) have Osteoarthritis.

Among these 39 people:

How long have people been on Clozaril when they have Osteoarthritis? *

What is the gender of people who have Osteoarthritis when taking Clozaril? *

female: 69.23 %
male: 30.77 %

What is the age of people who have Osteoarthritis when taking Clozaril? *

What are other drugs people take besides Clozaril? *

What are other side effects people have besides Osteoarthritis? *

Stress And Anxiety: 12 people, 30.77%
Back Pain: 11 people, 28.21%
Depression: 11 people, 28.21%
High Blood Pressure: 10 people, 25.64%
Fall: 10 people, 25.64%
Weakness: 9 people, 23.08%
Joint Pain: 9 people, 23.08%
Constipation: 9 people, 23.08%
Insomnia (sleeplessness): 8 people, 20.51%
Pain: 8 people, 20.51%

What are the existing conditions these people have? *

Depression: 8 people, 20.51%
Osteoporosis (bones weak and more likely to break): 7 people, 17.95%
Osteopenia (a condition where bone mineral density is lower than normal): 5 people, 12.82%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 7.69%
Metastases To Bone (cancer spreads to bone): 2 people, 5.13%
Sleep Disorder: 2 people, 5.13%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.13%
Salivary Hypersecretion (excess saliva secretion): 2 people, 5.13%
High Blood Cholesterol: 2 people, 5.13%
Stress And Anxiety: 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

Do you take Clozaril and have Osteoarthritis?

- Check whether Osteoarthritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clozaril:

Clozaril (65,127 reports)

Osteoarthritis treatments and more:

Osteoarthritis (95,655 reports)

Browse all side effects of Clozaril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoarthritis:

Osteoarthritis (1,878 drugs)

Browse all the conditions that are associated with Osteoarthritis:

Osteoarthritis (2,647 conditions)

Related publications that referenced our studies

Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
Yaylaci S, Yilmaz EU, Guclu E, Kumsar NA, Tamer A, Karabay O, "Clozapine-Induced Febrile Neutropenia and Cellulitis", Turkish journal of emergency medicine, 2014 Mar .
Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
Yaylaci S, Yilmaz EU, Guclu E, Kumsar NA, Tamer A, Karabay O, "Clozapine-Induced Febrile Neutropenia and Cellulitis", Turkish journal of emergency medicine, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on clozapine (the active ingredients of Clozaril) and Clozaril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.