Codeine and Hypercortisolism - a phase IV clinical study of FDA data

Summary:

Hypercortisolism is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 40-49 old, also take Spiriva, and have Asthma.

The phase IV clinical study analyzes which people have Hypercortisolism when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Hypercortisolism?

Hypercortisolism (excessive secretion of one or more steroid hormones of the adrenal cortex) is found to be associated with 867 drugs and 714 conditions by eHealthMe. Check the latest studies of Hypercortisolism.

On Sep, 29, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 22 people (0.05%) have Hypercortisolism.

Among these 22 people:

What is the gender of people who have Hypercortisolism when taking Codeine? *

female: 100 %
male: 0.0 %

What is the age of people who have Hypercortisolism when taking Codeine? *

What are other drugs people take besides Codeine? *

Xolair: 8 people, 36.36%
Symbicort: 8 people, 36.36%
Ventolin: 8 people, 36.36%
Spiriva: 8 people, 36.36%
Insulin: 6 people, 27.27%
Dilaudid: 6 people, 27.27%
Prednisone: 6 people, 27.27%
Prednisolone: 5 people, 22.73%
Celebrex: 4 people, 18.18%
Cetirizine Hydrochloride: 4 people, 18.18%

What are other side effects people have besides Hypercortisolism? *

Joint Pain: 13 people, 59.09%
Drug Hypersensitivity: 12 people, 54.55%
Urinary Tract Infection: 12 people, 54.55%
Stable Angina (a constant chest pain): 8 people, 36.36%
Dysstasia (difficulty in standing): 8 people, 36.36%
Dry Throat: 8 people, 36.36%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 8 people, 36.36%
Cough: 8 people, 36.36%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 8 people, 36.36%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 8 people, 36.36%

What are the existing conditions these people have? *

Asthma: 12 people, 54.55%
Cough: 8 people, 36.36%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 8 people, 36.36%
Urinary Tract Infection: 4 people, 18.18%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 4 people, 18.18%
Cellulitis (infection under the skin): 4 people, 18.18%
Temporal Arteritis (inflammation and damage to blood vessels that supply the head area): 3 people, 13.64%
Diarrhea: 3 people, 13.64%
Pancreatic Carcinoma Metastatic (pancreatic cancer- metastatic): 2 people, 9.09%
Diabetes: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Hypercortisolism?

- Check whether Hypercortisolism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercortisolism:

Hypercortisolism (867 drugs)

Browse all the conditions that are associated with Hypercortisolism:

Hypercortisolism (714 conditions)

Drugs similar to Codeine and Hypercortisolism :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.