Oxycodone and Hypercortisolism - a phase IV clinical study of FDA data

Summary:

Hypercortisolism is reported as a side effect among people who take Oxycodone (oxycodone hydrochloride), especially for people who are female, 50-59 old, also take Ibuprofen, and have Relapsing-remitting multiple sclerosis.

The phase IV clinical study analyzes which people have Hypercortisolism when taking Oxycodone. It is created by eHealthMe based on reports of 159,853 people who have side effects when taking Oxycodone from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,588 Oxycodone users. Check the latest studies of Oxycodone.

What is Hypercortisolism?

Hypercortisolism (excessive secretion of one or more steroid hormones of the adrenal cortex) is found to be associated with 818 drugs and 718 conditions by eHealthMe. Check the latest studies of Hypercortisolism.

On Dec, 17, 2025

159,853 people reported to have side effects when taking Oxycodone.
Among them, 72 people (0.05%) have Hypercortisolism.

Among these 72 people:

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and have Hypercortisolism?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone:

Oxycodone (162,588 reports)

Hypercortisolism treatments and more:

Hypercortisolism (8,369 reports)

How severe was Hypercortisolism and when was it recovered:

Hypercortisolism in Oxycodone

Expand to all the drugs that have ingredients of oxycodone hydrochloride:

Hypercortisolism and drugs with ingredients of oxycodone hydrochloride (80 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Oxycodone side effects:

Browse all side effects of Oxycodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Hypercortisolism:

Browse all the drugs that are associated with Hypercortisolism:

Hypercortisolism (818 drugs)

Common conditions associated with Hypercortisolism:

Browse all the conditions that are associated with Hypercortisolism:

Hypercortisolism (718 conditions)

Drugs similar to Oxycodone and Hypercortisolism :

How the study uses the data?

The study uses data from the FDA. It is based on oxycodone hydrochloride (the active ingredients of Oxycodone) and Oxycodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.