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Codeine and Hypertension - a phase IV clinical study of FDA data

Summary:

Hypertension is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Enbrel, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Hypertension when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Hypertension?

Hypertension (high blood pressure) is found to be associated with 4,674 drugs and 5,189 conditions by eHealthMe. Check the latest studies of Hypertension.

On Nov, 13, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 3,556 people (8.52%) have Hypertension.

Could Codeine cause Hypertension?

Among these 3,556 people:

How long have people been on Codeine when they have Hypertension? *

  • < 1 month: 88.89 %
  • 1 - 6 months: 5.56 %
  • 6 - 12 months: 5.56 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hypertension when taking Codeine? *

  • female: 89.14 %
  • male: 10.86 %

What is the age of people who have Hypertension when taking Codeine? *

  • 0-1: 0.0 %
  • 2-9: 0.08 %
  • 10-19: 0.37 %
  • 20-29: 0.78 %
  • 30-39: 5.52 %
  • 40-49: 30.4 %
  • 50-59: 29.42 %
  • 60+: 33.43 %

What are other drugs people take besides Codeine? *

  1. Enbrel: 2,056 people, 57.82%
  2. Humira: 1,876 people, 52.76%
  3. Orencia: 1,827 people, 51.38%
  4. Xeljanz: 1,736 people, 48.82%
  5. Remicade: 1,626 people, 45.73%
  6. Arava: 1,491 people, 41.93%
  7. Actemra: 1,422 people, 39.99%
  8. Prednisone: 1,321 people, 37.15%
  9. Acetaminophen: 1,300 people, 36.56%
  10. Simponi: 1,241 people, 34.90%

What are other side effects people have besides Hypertension? *

  1. Drug Ineffective: 1,983 people, 55.76%
  2. Headache (pain in head): 1,954 people, 54.95%
  3. Joint Pain: 1,839 people, 51.72%
  4. Rashes (redness): 1,820 people, 51.18%
  5. Drug Hypersensitivity: 1,752 people, 49.27%
  6. Fatigue (feeling of tiredness): 1,714 people, 48.20%
  7. Drug Intolerance (drug sensitivity): 1,685 people, 47.38%
  8. Joint Swelling: 1,608 people, 45.22%
  9. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1,544 people, 43.42%
  10. Diarrhea: 1,502 people, 42.24%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2,198 people, 61.81%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 532 people, 14.96%
  3. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 514 people, 14.45%
  4. Psoriasis (immune-mediated disease that affects the skin): 459 people, 12.91%
  5. Herpes Zoster: 311 people, 8.75%
  6. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 283 people, 7.96%
  7. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 268 people, 7.54%
  8. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 186 people, 5.23%
  9. Arthritis (form of joint disorder that involves inflammation of one or more joints): 164 people, 4.61%
  10. Ankylosing Spondylitis (type of arthritis affecting the spine): 141 people, 3.97%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Hypertension?

- Check whether Hypertension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Hypertension treatments and more:

How severe was Hypertension and when was it recovered:

Expand to all the drugs that have ingredients of codeine sulfate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Codeine side effects:

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Hypertension:

Browse all the drugs that are associated with Hypertension:

Common conditions associated with Hypertension:

Browse all the conditions that are associated with Hypertension:

Drugs similar to Codeine and Hypertension :

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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