Combipatch and Musculoskeletal pain - a phase IV clinical study of FDA data

Summary:

Musculoskeletal pain is reported as a side effect among people who take Combipatch (estradiol; norethindrone acetate), especially for people who are female, 40-49 old, have been taking the drug for 10+ years also take Provera, and have Osteoporosis.

The phase IV clinical study analyzes which people have Musculoskeletal pain when taking Combipatch. It is created by eHealthMe based on reports of 3,544 people who have side effects when taking Combipatch from the FDA, and is updated regularly.

What is Combipatch?

Combipatch has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 3,599 Combipatch users. Check the latest studies of Combipatch.

What is Musculoskeletal pain?

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves) is found to be associated with 1,881 drugs and 1,824 conditions by eHealthMe. Check the latest studies of Musculoskeletal pain.

On Jul, 13, 2026

3,544 people reported to have side effects when taking Combipatch.
Among them, 19 people (0.54%) have Musculoskeletal pain.

Could Combipatch cause Musculoskeletal pain?

Among these 19 people:

How long have people been on Combipatch when they have Musculoskeletal pain? *

What is the gender of people who have Musculoskeletal pain when taking Combipatch? *

female: 100 %
male: 0.0 %

What is the age of people who have Musculoskeletal pain when taking Combipatch? *

What are other drugs people take besides Combipatch? *

What are other side effects people have besides Musculoskeletal pain? *

Stress And Anxiety: 9 people, 47.37%
Breast Cancer: 9 people, 47.37%
Joint Pain: 8 people, 42.11%
Abdominal Distension: 7 people, 36.84%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 7 people, 36.84%
Muscle Aches (muscle pain): 6 people, 31.58%
Fibrocystic Breast Disease (a condition causing breast pain, cysts, and noncancerous breast lumps, affects many women): 6 people, 31.58%
Weakness: 6 people, 31.58%
Bone Pain: 6 people, 31.58%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 26.32%

What are the existing conditions these people have? *

Seasonal Allergy (allergic condition due to certain season): 4 people, 21.05%
Osteoporosis (bones weak and more likely to break): 4 people, 21.05%
Stress And Anxiety: 3 people, 15.79%
Sinusitis (inflammation of sinus): 3 people, 15.79%
Nausea (feeling of having an urge to vomit): 3 people, 15.79%
Vaginal Infection: 3 people, 15.79%
Hypersensitivity: 3 people, 15.79%
Dizziness: 3 people, 15.79%
Dermatitis Contact (skin reaction (dermatitis) resulting from exposure to allergens): 3 people, 15.79%
Vulvovaginal Dryness: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Combipatch and have Musculoskeletal pain?

- Check whether Musculoskeletal pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Combipatch:

Combipatch (3,599 reports)

Musculoskeletal pain treatments and more:

Musculoskeletal pain (77,217 reports)

How severe was Musculoskeletal pain and when was it recovered:

Musculoskeletal pain in Combipatch

Expand to all the drugs that have ingredients of estradiol; norethindrone acetate:

Musculoskeletal pain and drugs with ingredients of estradiol; norethindrone acetate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Combipatch:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Musculoskeletal pain:

Musculoskeletal pain (1,881 drugs)

Browse all the conditions that are associated with Musculoskeletal pain:

Musculoskeletal pain (1,824 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; norethindrone acetate (the active ingredients of Combipatch) and Combipatch (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.