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Depakene and Deep venous thrombosis - a phase IV clinical study of FDA data

Summary:

Deep venous thrombosis is reported as a side effect among people who take Depakene (valproic acid), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Zyprexa, and have Status epilepticus.

The phase IV clinical study analyzes which people have Deep venous thrombosis when taking Depakene. It is created by eHealthMe based on reports of 14,611 people who have side effects when taking Depakene from the FDA, and is updated regularly.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

What is Deep venous thrombosis?

Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis) is found to be associated with 2,070 drugs and 2,964 conditions by eHealthMe. Check the latest studies of Deep venous thrombosis.

On Jul, 16, 2026

14,611 people reported to have side effects when taking Depakene.
Among them, 38 people (0.26%) have Deep venous thrombosis.

Could Depakene cause Deep venous thrombosis?

Among these 38 people:

How long have people been on Depakene when they have Deep venous thrombosis? *

  • < 1 month: 62.5 %
  • 1 - 6 months: 25.0 %
  • 6 - 12 months: 12.5 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Deep venous thrombosis when taking Depakene? *

  • female: 33.33 %
  • male: 66.67 %

What is the age of people who have Deep venous thrombosis when taking Depakene? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 9.68 %
  • 30-39: 29.03 %
  • 40-49: 9.68 %
  • 50-59: 19.35 %
  • 60+: 32.26 %

What are other drugs people take besides Depakene? *

  1. Zyprexa: 8 people, 21.05%
  2. Methotrexate: 6 people, 15.79%
  3. Prednisolone: 5 people, 13.16%
  4. Cymbalta: 4 people, 10.53%
  5. Lamictal: 4 people, 10.53%
  6. Busulfan: 3 people, 7.89%
  7. Fludara: 3 people, 7.89%
  8. Prograf: 3 people, 7.89%
  9. Oxycontin: 3 people, 7.89%
  10. Zovirax: 3 people, 7.89%

What are other side effects people have besides Deep venous thrombosis? *

  1. Pulmonary Embolism (blockage of the main artery of the lung): 13 people, 34.21%
  2. Infection: 8 people, 21.05%
  3. Sepsis (a severe blood infection that can lead to organ failure and death): 8 people, 21.05%
  4. Colitis Ischaemic (due to infection of intestine impaired blood supply to colon): 8 people, 21.05%
  5. Pseudomembranous Colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon): 8 people, 21.05%
  6. Diarrhea: 7 people, 18.42%
  7. Autonomic Nervous System Imbalance (autonomic nervous system is of net equal emphasis): 6 people, 15.79%
  8. Bleeding Disorders: 6 people, 15.79%
  9. Fever: 6 people, 15.79%
  10. Hepatitis Fulminant (life-threatening condition defined by significantly impaired liver function): 6 people, 15.79%

What are the existing conditions these people have? *

  1. Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 6 people, 15.79%
  2. Psychotic Disorder: 3 people, 7.89%
  3. Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 3 people, 7.89%
  4. Insomnia (sleeplessness): 3 people, 7.89%
  5. Gastric Ulcer (stomach ulcer): 3 people, 7.89%
  6. Gastric Cancer (stomach cancer): 3 people, 7.89%
  7. Lung Cancer - Non-Small Cell (lung cancer): 2 people, 5.26%
  8. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.26%
  9. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 2 people, 5.26%
  10. Depressive Symptom: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Depakene and have Deep venous thrombosis?

- Check whether Deep venous thrombosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakene:

Deep venous thrombosis treatments and more:

How severe was Deep venous thrombosis and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Depakene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Deep venous thrombosis:

Browse all the conditions that are associated with Deep venous thrombosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Depakene) and Depakene (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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