Depakene and Gallstones - a phase IV clinical study of FDA data

Summary:

Gallstones is reported as a side effect among people who take Depakene (valproic acid), especially for people who are male, 40-49 old, have been taking the drug for 1 - 6 months also take Lasix, and have Acquired immunodeficiency syndrome.

The phase IV clinical study analyzes which people have Gallstones when taking Depakene. It is created by eHealthMe based on reports of 14,611 people who have side effects when taking Depakene from the FDA, and is updated regularly.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

What is Gallstones?

Gallstones (stone formation by bile component) is found to be associated with 1,804 drugs and 2,101 conditions by eHealthMe. Check the latest studies of Gallstones.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

14,611 people reported to have side effects when taking Depakene.
Among them, 32 people (0.22%) have Gallstones.

Among these 32 people:

How long have people been on Depakene when they have Gallstones? *

What is the gender of people who have Gallstones when taking Depakene? *

female: 35.48 %
male: 64.52 %

What is the age of people who have Gallstones when taking Depakene? *

What are other drugs people take besides Depakene? *

What are other side effects people have besides Gallstones? *

Hepatic Function Abnormal: 12 people, 37.50%
Fever: 9 people, 28.12%
Haemoglobin Decreased: 9 people, 28.12%
Aspartate Aminotransferase Increased: 9 people, 28.12%
Dizziness: 8 people, 25.00%
Abdominal Pain Upper: 8 people, 25.00%
Diarrhea: 7 people, 21.88%
Hyperlactacidaemia (the acidosis and also reduces the capacity of the kidney): 7 people, 21.88%
Blood Uric Acid Increased: 7 people, 21.88%
Weakness: 7 people, 21.88%

What are the existing conditions these people have? *

Acquired Immunodeficiency Syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv)): 7 people, 21.88%
Neck Pain: 5 people, 15.62%
The Flu (the flu is caused by an influenza virus): 5 people, 15.62%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 5 people, 15.62%
Headache (pain in head): 5 people, 15.62%
Pain In Jaw: 5 people, 15.62%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 15.62%
Pain: 3 people, 9.38%
Depression: 2 people, 6.25%
High Blood Pressure: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Depakene and have Gallstones?

- Check whether Gallstones is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakene:

Depakene (14,776 reports)

Gallstones treatments and more:

Gallstones (50,126 reports)

Browse all side effects of Depakene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gallstones:

Gallstones (1,804 drugs)

Browse all the conditions that are associated with Gallstones:

Gallstones (2,101 conditions)

Related publications that referenced our studies

Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
Hwabejire JO, Lu J, Liu B, Li Y, Halaweish I, Alam HB, "Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study", journal of surgical research, 2014 Jan .
Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
Hwabejire JO, Lu J, Liu B, Li Y, Halaweish I, Alam HB, "Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study", journal of surgical research, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Depakene) and Depakene (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.