Lamictal vs. Prozac


We compare the side effects and drug effectiveness of Lamictal and Prozac. The study is created by eHealthMe based on reports of 218,932 people who take Lamictal and Prozac, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on lamotrigine and fluoxetine hydrochloride (the active ingredients of Lamictal and Prozac, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered.

What is Lamictal?

Lamictal has active ingredients of lamotrigine. It is often used in bipolar disorder. (latest outcomes from Lamictal 64,115 users)

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. (latest outcomes from Prozac 65,791 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

On Feb, 28, 2019

218,932 people who take Lamictal and Prozac are studied.

Number of reports submitted per year:

Lamictal vs Prozac drug comparison reports.

Drugs in this study:

  • Prozac (fluoxetine hydrochloride)
  • Lamictal (lamotrigine)

Most common side effects:

  1. Nausea (feeling of having an urge to vomit)
  2. Fatigue (feeling of tiredness)
  3. Drug Ineffective
  4. Headache (pain in head)
  5. Pain
  6. Dyspnoea (difficult or laboured respiration)
  7. Vomiting
  8. Diarrhoea
  9. Dizziness
  10. Fall
  1. Rash
  2. Drug Ineffective
  3. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  4. Pyrexia (fever)
  5. Nausea (feeling of having an urge to vomit)
  6. Headache (pain in head)
  7. Dizziness
  8. Fatigue (feeling of tiredness)
  9. Vomiting
  10. Insomnia (sleeplessness)

Most common side effects experienced by people in long term use:

  1. Pain
  2. Fatigue (feeling of tiredness)
  3. Nausea (feeling of having an urge to vomit)
  4. Suicidal Ideation
  5. Drug Ineffective
  6. Dizziness
  7. Headache (pain in head)
  8. Dyspnoea (difficult or laboured respiration)
  9. Weight Increased
  10. Suicide Attempt
  1. Rash
  2. Drug Ineffective
  3. Dizziness
  4. Fatigue (feeling of tiredness)
  5. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  6. Nausea (feeling of having an urge to vomit)
  7. Headache (pain in head)
  8. Insomnia (sleeplessness)
  9. Tremor (trembling or shaking movements in one or more parts of your body)
  10. Pain

Drug effectiveness:

  • not at all: 4.19 %
  • somewhat: 22.7 %
  • moderate: 35.55 %
  • high: 29.14 %
  • very high: 8.42 %
  • not at all: 3.44 %
  • somewhat: 18.23 %
  • moderate: 30.57 %
  • high: 31.14 %
  • very high: 16.62 %

Do you take Lamictal or Prozac?

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WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.