Depo-provera and Heart attack - a phase IV clinical study of FDA data

Summary:

Heart attack is reported as a side effect among people who take Depo-provera (medroxyprogesterone acetate), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Yaz, and have Pain.

The phase IV clinical study analyzes which people have Heart attack when taking Depo-provera. It is created by eHealthMe based on reports of 15,804 people who have side effects when taking Depo-provera from the FDA, and is updated regularly.

What is Depo-provera?

Depo-provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 17,093 Depo-provera users. Check the latest studies of Depo-provera.

What is Heart attack?

Heart attack is found to be associated with 2,473 drugs and 3,298 conditions by eHealthMe. Check the latest studies of Heart attack.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

15,804 people reported to have side effects when taking Depo-provera.
Among them, 66 people (0.42%) have Heart attack.

Among these 66 people:

How long have people been on Depo-provera when they have Heart attack? *

What is the gender of people who have Heart attack when taking Depo-provera? *

female: 96.92 %
male: 3.08 %

What is the age of people who have Heart attack when taking Depo-provera? *

What are other drugs people take besides Depo-provera? *

What are other side effects people have besides Heart attack? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 16 people, 24.24%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 10 people, 15.15%
Chest Pain: 9 people, 13.64%
Pulmonary Embolism (blockage of the main artery of the lung): 7 people, 10.61%
Abdominal Pain Upper: 7 people, 10.61%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 7 people, 10.61%
Dyspnea (difficult or laboured breathing): 7 people, 10.61%
High Blood Pressure: 7 people, 10.61%
Pain: 7 people, 10.61%
Angina Unstable (chest pain due to ischemia of the heart muscle- unstable): 6 people, 9.09%

What are the existing conditions these people have? *

Pain: 5 people, 7.58%
High Blood Pressure: 4 people, 6.06%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 4 people, 6.06%
Quit Smoking: 4 people, 6.06%
Multiple Allergies (allergy to multiple agents): 4 people, 6.06%
Asthma: 3 people, 4.55%
Diabetes: 3 people, 4.55%
Type 2 Diabetes: 3 people, 4.55%
Acne (skin problems that cause pimples): 3 people, 4.55%
Premenstrual Syndrome: 2 people, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Depo-provera and have Heart attack?

- Check whether Heart attack is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depo-provera:

Depo-provera (17,093 reports)

Heart attack treatments and more:

Heart attack (266,145 reports)

Browse all side effects of Depo-provera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart attack:

Heart attack (2,473 drugs)

Browse all the conditions that are associated with Heart attack:

Heart attack (3,298 conditions)

Related publications that referenced our studies

Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .
Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on medroxyprogesterone acetate (the active ingredients of Depo-provera) and Depo-provera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.