Depo-provera and Mania aggravated - a phase IV clinical study of FDA data

Summary:

Mania aggravated is reported as a side effect among people who take Depo-provera (medroxyprogesterone acetate), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Lexapro, and have Depression.

The phase IV clinical study analyzes which people have Mania aggravated when taking Depo-provera. It is created by eHealthMe based on reports of 15,804 people who have side effects when taking Depo-provera from the FDA, and is updated regularly.

What is Depo-provera?

Depo-provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 17,093 Depo-provera users. Check the latest studies of Depo-provera.

What is Mania aggravated?

Mania aggravated (irritable mood) is found to be associated with 812 drugs and 373 conditions by eHealthMe. Check the latest studies of Mania aggravated.

On Jun, 17, 2026

15,804 people reported to have side effects when taking Depo-provera.
Among them, 30 people (0.19%) have Mania aggravated.

Could Depo-provera cause Mania aggravated?

Among these 30 people:

How long have people been on Depo-provera when they have Mania aggravated? *

What is the gender of people who have Mania aggravated when taking Depo-provera? *

female: 96.43 %
male: 3.57 %

What is the age of people who have Mania aggravated when taking Depo-provera? *

What are other drugs people take besides Depo-provera? *

What are other side effects people have besides Mania aggravated? *

Depression: 6 people, 20.00%
Mood Swings (an extreme or rapid change in mood): 6 people, 20.00%
Stress And Anxiety: 5 people, 16.67%
Weight Increased: 4 people, 13.33%
Insomnia (sleeplessness): 4 people, 13.33%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 4 people, 13.33%
Hair Loss: 3 people, 10.00%
Nausea (feeling of having an urge to vomit): 3 people, 10.00%
Nausea And Vomiting: 3 people, 10.00%
Nervousness: 3 people, 10.00%

What are the existing conditions these people have? *

Asthma: 3 people, 10.00%
Depression: 3 people, 10.00%
Impaired Gastric Emptying: 2 people, 6.67%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 6.67%
Bipolar Disorder (mood disorder): 2 people, 6.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 6.67%
Muscle Spasms (muscle contraction): 2 people, 6.67%
Multiple Allergies (allergy to multiple agents): 2 people, 6.67%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 1 person, 3.33%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Depo-provera and have Mania aggravated?

- Check whether Mania aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depo-provera:

Depo-provera (17,093 reports)

Browse all side effects of Depo-provera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mania aggravated:

Mania aggravated (812 drugs)

Browse all the conditions that are associated with Mania aggravated:

Mania aggravated (373 conditions)

Related publications that referenced our studies

Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .
Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on medroxyprogesterone acetate (the active ingredients of Depo-provera) and Depo-provera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.