Dexamethasone and Hyperosmolar state - a phase IV clinical study of FDA data

Summary:

Hyperosmolar state is reported as a side effect among people who take Dexamethasone (dexamethasone), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Megace, and have Gastritis.

The phase IV clinical study analyzes which people have Hyperosmolar state when taking Dexamethasone. It is created by eHealthMe based on reports of 161,257 people who have side effects when taking Dexamethasone from the FDA, and is updated regularly.

What is Dexamethasone?

Dexamethasone has active ingredients of dexamethasone. It is often used in multiple myeloma. eHealthMe is studying from 161,927 Dexamethasone users. Check the latest studies of Dexamethasone.

What is Hyperosmolar state?

Hyperosmolar state (life-threatening emergency manifested by marked elevation of blood glucose) is found to be associated with 69 drugs and 258 conditions by eHealthMe. Check the latest studies of Hyperosmolar state.

On Jul, 11, 2026

161,257 people reported to have side effects when taking Dexamethasone.
Among them, 13 people (0.01%) have Hyperosmolar state.

Could Dexamethasone cause Hyperosmolar state?

Among these 13 people:

How long have people been on Dexamethasone when they have Hyperosmolar state? *

What is the gender of people who have Hyperosmolar state when taking Dexamethasone? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Hyperosmolar state when taking Dexamethasone? *

What are other drugs people take besides Dexamethasone? *

Myfortic: 2 people, 15.38%
Aspirin: 2 people, 15.38%
Bisoprolol Fumarate: 2 people, 15.38%
Ceftriaxone: 2 people, 15.38%
Megace: 2 people, 15.38%
Zyrtec: 1 person, 7.69%
Hydrochlorothiazide: 1 person, 7.69%
Glipizide: 1 person, 7.69%
Gemcitabine Hydrochloride: 1 person, 7.69%
Gabapentin: 1 person, 7.69%

What are other side effects people have besides Hyperosmolar state? *

Weakness: 7 people, 53.85%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 5 people, 38.46%
Thrombocytopenia (decrease of platelets in blood): 4 people, 30.77%
Diabetic Ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 3 people, 23.08%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 23.08%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 23.08%
Fever: 3 people, 23.08%
Dyspnea (difficult or laboured breathing): 3 people, 23.08%
Hypoglycemia (low blood sugar): 3 people, 23.08%
Hyperglycemia (high blood sugar): 3 people, 23.08%

What are the existing conditions these people have? *

Urinary Tract Infection: 2 people, 15.38%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 15.38%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 2 people, 15.38%
Gastritis (inflammation of stomach): 2 people, 15.38%
Type 2 Diabetes: 1 person, 7.69%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 1 person, 7.69%
Hyperglycemia (high blood sugar): 1 person, 7.69%
Hiv Infection: 1 person, 7.69%
Dehydration (dryness resulting from the removal of water): 1 person, 7.69%
Appetite - Increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Dexamethasone and have Hyperosmolar state?

- Check whether Hyperosmolar state is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dexamethasone:

Dexamethasone (161,927 reports)

Browse all side effects of Dexamethasone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperosmolar state:

Hyperosmolar state (69 drugs)

Browse all the conditions that are associated with Hyperosmolar state:

Hyperosmolar state (258 conditions)

Related publications that referenced our studies

Bartlett R, Hartle AJ, "Routine use of dexamethasone for postoperative nausea and vomiting: the case against", Anaesthesia, 2013 Sep .
Bartlett R, Hartle AJ, "Routine use of dexamethasone for postoperative nausea and vomiting: the case against", Anaesthesia, 2013 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on dexamethasone (the active ingredients of Dexamethasone) and Dexamethasone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.