Dexamethasone and Withdrawal syndrome - a phase IV clinical study of FDA data

Summary:

Withdrawal syndrome is reported as a side effect among people who take Dexamethasone (dexamethasone), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Atenolol, and have Depression.

The phase IV clinical study analyzes which people have Withdrawal syndrome when taking Dexamethasone. It is created by eHealthMe based on reports of 161,257 people who have side effects when taking Dexamethasone from the FDA, and is updated regularly.

What is Dexamethasone?

Dexamethasone has active ingredients of dexamethasone. It is often used in multiple myeloma. eHealthMe is studying from 161,927 Dexamethasone users. Check the latest studies of Dexamethasone.

What is Withdrawal syndrome?

Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) is found to be associated with 1,004 drugs and 1,486 conditions by eHealthMe. Check the latest studies of Withdrawal syndrome.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

161,257 people reported to have side effects when taking Dexamethasone.
Among them, 48 people (0.03%) have Withdrawal syndrome.

Could Dexamethasone cause Withdrawal syndrome?

Among these 48 people:

How long have people been on Dexamethasone when they have Withdrawal syndrome? *

What is the gender of people who have Withdrawal syndrome when taking Dexamethasone? *

female: 34.78 %
male: 65.22 %

What is the age of people who have Withdrawal syndrome when taking Dexamethasone? *

What are other drugs people take besides Dexamethasone? *

What are other side effects people have besides Withdrawal syndrome? *

Hypotension (abnormally low blood pressure): 9 people, 18.75%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 9 people, 18.75%
Hypovolaemia (a decreased volume of circulating blood in the body): 7 people, 14.58%
Drug Ineffective: 6 people, 12.50%
Agitation (state of anxiety or nervous excitement): 5 people, 10.42%
High Blood Pressure: 4 people, 8.33%
Fall: 4 people, 8.33%
Weakness: 4 people, 8.33%
Salivary Hypersecretion (excess saliva secretion): 3 people, 6.25%
Insomnia (sleeplessness): 3 people, 6.25%

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 8.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 8.33%
Depression: 4 people, 8.33%
Urinary Tract Infection: 3 people, 6.25%
Upper Airway Obstruction: 3 people, 6.25%
Sedation: 3 people, 6.25%
Constipation: 3 people, 6.25%
Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 3 people, 6.25%
Delusion (a false belief or opinion): 3 people, 6.25%
Dexamethasone Suppression Test: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Dexamethasone and have Withdrawal syndrome?

- Check whether Withdrawal syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dexamethasone:

Dexamethasone (161,927 reports)

Browse all side effects of Dexamethasone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Withdrawal syndrome:

Withdrawal syndrome (1,004 drugs)

Browse all the conditions that are associated with Withdrawal syndrome:

Withdrawal syndrome (1,486 conditions)

Related publications that referenced our studies

Bartlett R, Hartle AJ, "Routine use of dexamethasone for postoperative nausea and vomiting: the case against", Anaesthesia, 2013 Sep .
Bartlett R, Hartle AJ, "Routine use of dexamethasone for postoperative nausea and vomiting: the case against", Anaesthesia, 2013 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on dexamethasone (the active ingredients of Dexamethasone) and Dexamethasone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.