Dilantin and Restless leg syndrome - a phase IV clinical study of FDA data

Summary:

Restless leg syndrome is reported as a side effect among people who take Dilantin (phenytoin sodium), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Flomax, and have Osteoporosis.

The phase IV clinical study analyzes which people have Restless leg syndrome when taking Dilantin. It is created by eHealthMe based on reports of 19,857 people who have side effects when taking Dilantin from the FDA, and is updated regularly.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

What is Restless leg syndrome?

Restless leg syndrome (a powerful urge to move your legs) is found to be associated with 1,246 drugs and 1,934 conditions by eHealthMe. Check the latest studies of Restless leg syndrome.

On Jul, 13, 2026

19,857 people reported to have side effects when taking Dilantin.
Among them, 38 people (0.19%) have Restless leg syndrome.

Could Dilantin cause Restless leg syndrome?

Among these 38 people:

How long have people been on Dilantin when they have Restless leg syndrome? *

What is the gender of people who have Restless leg syndrome when taking Dilantin? *

female: 57.89 %
male: 42.11 %

What is the age of people who have Restless leg syndrome when taking Dilantin? *

What are other drugs people take besides Dilantin? *

What are other side effects people have besides Restless leg syndrome? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 29 people, 76.32%
Dyspnea (difficult or laboured breathing): 22 people, 57.89%
Nausea (feeling of having an urge to vomit): 19 people, 50.00%
Back Pain: 19 people, 50.00%
Asthma: 17 people, 44.74%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 17 people, 44.74%
Pain: 17 people, 44.74%
Pneumonia: 17 people, 44.74%
Dizziness: 16 people, 42.11%
Fatigue (feeling of tiredness): 16 people, 42.11%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 11 people, 28.95%
Pain: 6 people, 15.79%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 6 people, 15.79%
High Blood Pressure: 2 people, 5.26%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.26%
Spondylosis (a defect of a vertebra): 2 people, 5.26%
Cerebral Sarcoidosis (small areas of inflammation in brain): 1 person, 2.63%
Depression: 1 person, 2.63%
Diabetes: 1 person, 2.63%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Dilantin and have Restless leg syndrome?

- Check whether Restless leg syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dilantin:

Dilantin (20,858 reports)

Browse all side effects of Dilantin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Restless leg syndrome:

Restless leg syndrome (1,246 drugs)

Browse all the conditions that are associated with Restless leg syndrome:

Restless leg syndrome (1,934 conditions)

Related publications that referenced our studies

Akasaka E, Kayo SJ, Nakano H, Ishii N, Hashimoto T, Sawamura D, "Diaminodiphenyl Sulfone-Induced Hemolytic Anemia and Alopecia in a Case of Linear IgA Bullous Dermatosis", Case reports in dermatology, 2014 Jan .
Akasaka E, Kayo SJ, Nakano H, Ishii N, Hashimoto T, Sawamura D, "Diaminodiphenyl Sulfone-Induced Hemolytic Anemia and Alopecia in a Case of Linear IgA Bullous Dermatosis", Case reports in dermatology, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on phenytoin sodium (the active ingredients of Dilantin) and Dilantin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.