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Dilaudid and Toxic encephalopathy - a phase IV clinical study of FDA data

Summary:

Toxic encephalopathy is reported as a side effect among people who take Dilaudid (hydromorphone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Percocet, and have On and off phenomenon.

The phase IV clinical study analyzes which people have Toxic encephalopathy when taking Dilaudid. It is created by eHealthMe based on reports of 95,518 people who have side effects when taking Dilaudid from the FDA, and is updated regularly.

What is Dilaudid?

Dilaudid has active ingredients of hydromorphone hydrochloride. It is often used in pain. eHealthMe is studying from 96,466 Dilaudid users. Check the latest studies of Dilaudid.

What is Toxic encephalopathy?

Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances) is found to be associated with 423 drugs and 617 conditions by eHealthMe. Check the latest studies of Toxic encephalopathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

95,518 people reported to have side effects when taking Dilaudid.
Among them, 35 people (0.04%) have Toxic encephalopathy.

Could Dilaudid cause Toxic encephalopathy?

Among these 35 people:

How long have people been on Dilaudid when they have Toxic encephalopathy? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Toxic encephalopathy when taking Dilaudid? *

  • female: 38.24 %
  • male: 61.76 %

What is the age of people who have Toxic encephalopathy when taking Dilaudid? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 22.22 %
  • 30-39: 11.11 %
  • 40-49: 3.7 %
  • 50-59: 3.7 %
  • 60+: 59.26 %

What are other drugs people take besides Dilaudid? *

  1. Percocet: 20 people, 57.14%
  2. Ms Contin: 12 people, 34.29%
  3. Heparin: 11 people, 31.43%
  4. Hydrocodone Bitartrate And Acetaminophen: 9 people, 25.71%
  5. Vicodin: 9 people, 25.71%
  6. Simvastatin: 9 people, 25.71%
  7. Haldol: 9 people, 25.71%
  8. Clonazepam: 9 people, 25.71%
  9. Lorazepam: 9 people, 25.71%
  10. Oxycontin: 8 people, 22.86%

What are other side effects people have besides Toxic encephalopathy? *

  1. Pneumonia: 19 people, 54.29%
  2. Memory Loss: 13 people, 37.14%
  3. Drug Dependence: 9 people, 25.71%
  4. Ileus Paralytic (obstruction of the intestine due to paralysis of the intestinal muscles): 9 people, 25.71%
  5. Urinary Tract Infection: 8 people, 22.86%
  6. Confusional State: 8 people, 22.86%
  7. Hallucinations (sensations that appear real but are created by your mind): 7 people, 20.00%
  8. Dehydration (dryness resulting from the removal of water): 6 people, 17.14%
  9. Drowsiness: 6 people, 17.14%
  10. Dyskinesia (abnormality or impairment of voluntary movement): 6 people, 17.14%

What are the existing conditions these people have? *

  1. On And Off Phenomenon: 8 people, 22.86%
  2. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 20.00%
  3. Parkinson's Disease: 5 people, 14.29%
  4. Stress And Anxiety: 3 people, 8.57%
  5. Back Pain: 2 people, 5.71%
  6. Metastases To Bone (cancer spreads to bone): 1 person, 2.86%
  7. Back Disorder: 1 person, 2.86%
  8. Breakthrough Pain: 1 person, 2.86%
  9. Constipation: 1 person, 2.86%
  10. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Dilaudid and have Toxic encephalopathy?

- Check whether Toxic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dilaudid:

Toxic encephalopathy treatments and more:

How severe was Toxic encephalopathy and when was it recovered:

Expand to all the drugs that have ingredients of hydromorphone hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dilaudid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Toxic encephalopathy:

Browse all the conditions that are associated with Toxic encephalopathy:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on hydromorphone hydrochloride (the active ingredients of Dilaudid) and Dilaudid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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