Divalproex sodium and Skin blushing/flushing - a phase IV clinical study of FDA data

Summary:

Skin blushing/flushing is reported as a side effect among people who take Divalproex sodium (divalproex sodium), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Depakote, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Skin blushing/flushing when taking Divalproex sodium. It is created by eHealthMe based on reports of 9,295 people who have side effects when taking Divalproex sodium from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Skin blushing/flushing?

Skin blushing/flushing (a sudden reddening of the face, neck) is found to be associated with 2,009 drugs and 2,936 conditions by eHealthMe. Check the latest studies of Skin blushing/flushing.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

9,295 people reported to have side effects when taking Divalproex sodium.
Among them, 56 people (0.6%) have Skin blushing/flushing.

Could Divalproex sodium cause Skin blushing/flushing?

Among these 56 people:

How long have people been on Divalproex sodium when they have Skin blushing/flushing? *

What is the gender of people who have Skin blushing/flushing when taking Divalproex sodium? *

female: 65.31 %
male: 34.69 %

What is the age of people who have Skin blushing/flushing when taking Divalproex sodium? *

What are other drugs people take besides Divalproex sodium? *

What are other side effects people have besides Skin blushing/flushing? *

Dyspnea (difficult or laboured breathing): 13 people, 23.21%
Diarrhea: 13 people, 23.21%
Infusion Site Erythema (reddening of the skin at infusion site): 12 people, 21.43%
Memory Loss: 11 people, 19.64%
Fainting (loss of consciousness and postural tone): 11 people, 19.64%
Weakness: 11 people, 19.64%
Itching: 11 people, 19.64%
Chills (felling of cold): 11 people, 19.64%
Weight Decreased: 10 people, 17.86%
Heart Rate Increased: 10 people, 17.86%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 19.64%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 10.71%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 6 people, 10.71%
Insomnia (sleeplessness): 5 people, 8.93%
Depression: 5 people, 8.93%
Nausea (feeling of having an urge to vomit): 4 people, 7.14%
Immunodeficiency Common Variable: 4 people, 7.14%
Nausea And Vomiting: 3 people, 5.36%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 5.36%
Constipation: 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

Do you take Divalproex sodium and have Skin blushing/flushing?

- Check whether Skin blushing/flushing is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Divalproex sodium:

Divalproex sodium (9,483 reports)

Browse all side effects of Divalproex sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin blushing/flushing:

Skin blushing/flushing (2,009 drugs)

Browse all the conditions that are associated with Skin blushing/flushing:

Skin blushing/flushing (2,936 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Divalproex sodium) and Divalproex sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.